Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Magnetically controlled pill could boost body's absorption of drugs

18.01.2011
Do you want that in a pill or a shot? A pill, thank you, but most patients never have that choice. The problem with administering many medications orally is that a pill often will not dissolve at exactly the right site in the gastrointestinal tract where the medicine can be absorbed into the bloodstream.

A new magnetic pill system developed by Brown University researchers could solve the problem by safely holding a pill in place in the intestine wherever it needs to be.

The scientists describe the harmless operation of their magnetic pill system in rats online the week of Jan. 17 in the Proceedings of the National Academy of Sciences. Applied to people in the future, said senior author Edith Mathiowitz, the technology could provide a new way to deliver many drugs to patients, including those with cancer or diabetes. It could also act as a powerful research tool to help scientists understand exactly where in the intestine different drugs are best absorbed.

"With this technology you can now tell where the pill is placed, take some blood samples and know exactly if the pill being in this region really enhances the bioavailability of the medicine in the body," said Mathiowitz, professor of medical science in Brown's Department of Molecular Pharmacology, Physiology, and Biotechnology. "It's a completely new way to design a drug delivery system."

The two main components of the system are conventional-looking gelatin capsules that contain a tiny magnet, and an external magnet that can precisely sense the force between it and the pill and vary that force, as needed, to hold the pill in place. The external magnet can sense the pill's position, but because the pill is opaque to x-rays, the researchers were also able to see the pill in the rat's bodies during their studies.

Safety first

The system is not the first attempt to guide pills magnetically, but it is the first one in which scientists can control the forces on a pill so that it's safe to use in the body. They designed their system to sense the position of pills and hold them there with a minimum of force.

"The most important thing is to be able to monitor the forces that you exert on the pill in order to avoid damage to the surrounding tissue," said Mathiowitz. "If you apply a little more than necessary force, your pill will be pulled to the external magnet, and this is a problem."

To accomplish this, the team including lead author and former graduate student Bryan Laulicht took careful measurements and built an external magnet system with sophisticated computer control and feedback mechanisms.

"The greatest challenges were quantifying the required force range for maintaining a magnetic pill in the small intestines and constructing a device that could maintain intermagnetic forces within that range," said Laulicht, who is now a postdoctoral scholar at MIT.

Even after holding a pill in place for 12 hours in the rats, the system applied a pressure on the intestinal wall that was less than 1/60th of what would be damaging.

The next step in the research is to begin delivering drugs using the system and testing their absorption, Mathiowitz and Laulicht said.

"Then it will move to larger animal models and ultimately into the clinic," Laulicht said. "It is my hope that magnetic pill retention will be used to enable oral drug delivery solutions to previously unmet medical needs."

In addition to Mathiowitz and Laulicht, authors on the paper include Brown researchers Nicholas Gidmark and Anubhav Tripathi. Brown University funded the research.

David Orenstein | EurekAlert!
Further information:
http://www.brown.edu

More articles from Medical Engineering:

nachricht Skin patch dissolves 'love handles' in mice
18.09.2017 | Columbia University Medical Center

nachricht Medicine of the future: New microchip technology could be used to track 'smart pills'
13.09.2017 | California Institute of Technology

All articles from Medical Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Highly precise wiring in the Cerebral Cortex

Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.

The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...

Im Focus: Tiny lasers from a gallery of whispers

New technique promises tunable laser devices

Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...

Im Focus: Ultrafast snapshots of relaxing electrons in solids

Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!

When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...

Im Focus: Quantum Sensors Decipher Magnetic Ordering in a New Semiconducting Material

For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.

Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...

Im Focus: Fast, convenient & standardized: New lab innovation for automated tissue engineering & drug

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

Comet or asteroid? Hubble discovers that a unique object is a binary

21.09.2017 | Physics and Astronomy

Cnidarians remotely control bacteria

21.09.2017 | Life Sciences

Monitoring the heart's mitochondria to predict cardiac arrest?

21.09.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>