Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


New imaging technique can diagnose common heart condition

Technique to measure blood flow is first to diagnose aortic disease and may predict complications

A new imaging technique for measuring blood flow in the heart and vessels can diagnose a common congenital heart abnormality, bicuspid aortic valve, and may lead to better prediction of complications.

A Northwestern Medicine team reported the finding in the journal Circulation. In the study, the authors demonstrated for the first time a previously unknown relationship between heart valve abnormalities, blood flow changes in the heart and aortic disease. They showed that blood flow changes were driven by specific types of abnormal aortic valves, and they were able to directly associate blood flow patterns with aortic diseases.

"Blood flow in patients with bicuspid aortic valves was significantly different compared to that in patients with normal valves," said senior author Michael Markl, associate professor of radiology at Northwestern University Feinberg School of Medicine. "We now have direct evidence that bicuspid valves induce changes in blood flow and that the type of flow abnormality may contribute to the development of different expressions of heart disease in these patients."

Bicuspid aortic valve is a heart condition in which the aortic valve only has two leaflets, instead of the normal three. It affects approximately one to two of every 100 Americans and is the most common congenital cardiovascular abnormality. Despite the absence of symptoms, the condition can lead to significant and potentially life-threatening complications, including enlargement of the blood vessel (aneurysm) and rupture. However, it is not known which patients are at the highest risk for complications and whether the condition's origin is genetic or related to changes in blood flow.

The 4D flow MRI (magnetic resonance imaging) used in the study has the potential for better predictive ability.

"The study demonstrated that new imaging techniques may help to determine patient-specific changes in blood flow to better understand which regional areas of the aorta are most prone to developing disease," Markl said. "In addition, the knowledge of abnormal blood flow patterns could be important to better identify patients at risk for the development of heart disease."

Markl's team was surprised to see such a clear distinction between individual expressions of aortic complications for different types of congenital valve disease. While the current findings show evidence of this link, long-term observational studies are needed to better understand the potential of 4D flow MRI to improve disease prediction ability.

A longitudinal follow-up study in patients with bicuspid aortic valves is currently underway at Northwestern.

"Ultimately, we hope that this imaging technique will facilitate early identification of high-risk blood flow patterns associated with progressive aortic enlargement, improving the allocation of health care resources in caring for patients with this prevalent condition," Markl said.

This research was supported by the National Heart, Lung and Blood Institute of the National Institutes of Health (NIH), grant R01HL115828, and by Northwestern University Clinical and Translational Sciences Institute NIH grant UL1RR025741. The research also was supported by the Northwestern Memorial Foundation Dixon Translational Research Grants Initiative, American Heart Association Scientist Development Grant and the Northwestern Bicuspid Aortic Valve Program at the Bluhm Cardiovascular Institute.

Related videos are available at:

Marla Paul | EurekAlert!
Further information:

Further reports about: Heart MRI Medicine Translational Research aortic valve blood flow heart disease

More articles from Medical Engineering:

nachricht Münster researchers make a fly’s heartbeat visible / Software automatically recognizes pulse
12.03.2018 | Westfälische Wilhelms-Universität Münster

nachricht 3-D-written model to provide better understanding of cancer spread
05.03.2018 | Purdue University

All articles from Medical Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Locomotion control with photopigments

Researchers from Göttingen University discover additional function of opsins

Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...

Im Focus: Surveying the Arctic: Tracking down carbon particles

Researchers embark on aerial campaign over Northeast Greenland

On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...

Im Focus: Unique Insights into the Antarctic Ice Shelf System

Data collected on ocean-ice interactions in the little-researched regions of the far south

The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...

Im Focus: ILA 2018: Laser alternative to hexavalent chromium coating

At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.

When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...

Im Focus: Radar for navigation support from autonomous flying drones

At the ILA Berlin, hall 4, booth 202, Fraunhofer FHR will present two radar sensors for navigation support of drones. The sensors are valuable components in the implementation of autonomous flying drones: they function as obstacle detectors to prevent collisions. Radar sensors also operate reliably in restricted visibility, e.g. in foggy or dusty conditions. Due to their ability to measure distances with high precision, the radar sensors can also be used as altimeters when other sources of information such as barometers or GPS are not available or cannot operate optimally.

Drones play an increasingly important role in the area of logistics and services. Well-known logistic companies place great hope in these compact, aerial...

All Focus news of the innovation-report >>>



Industry & Economy
Event News

Ultrafast Wireless and Chip Design at the DATE Conference in Dresden

16.03.2018 | Event News

International Tinnitus Conference of the Tinnitus Research Initiative in Regensburg

13.03.2018 | Event News

International Virtual Reality Conference “IEEE VR 2018” comes to Reutlingen, Germany

08.03.2018 | Event News

Latest News

Wandering greenhouse gas

16.03.2018 | Earth Sciences

'Frequency combs' ID chemicals within the mid-infrared spectral region

16.03.2018 | Physics and Astronomy

Biologists unravel another mystery of what makes DNA go 'loopy'

16.03.2018 | Life Sciences

Science & Research
Overview of more VideoLinks >>>