Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Combined imaging technologies may better identify cancerous breast lesions

09.11.2010
By combining optical and x-ray imaging, radiologists may be better able to distinguish cancer from benign lesions in the breast, according to a new study published in the online edition and January issue of Radiology.

Researchers at Martinos Center for Biomedical Imaging at Massachusetts General Hospital in Boston helped develop a combined optical/x-ray imaging system capable of obtaining both structural and functional information of the breast.

The two technologies used were digital breast tomosynthesis (DBT), a three-dimensional application of digital mammography, and diffuse optical tomography (DOT), which measures levels of hemoglobin concentration, oxygen saturation and other cellular characteristics, based on how light from a near-infrared laser is absorbed and scattered within tissue.

"By co-registering optical and x-ray data, radiologists are able to map suspicious findings and analyze the functional characteristics of those areas," said lead researcher Qianqian Fang, Ph.D., a radiology instructor at Harvard Medical School.

In the study, combined DBT and DOT was performed on 189 breasts from 125 women with an average age of 56 years. To perform the procedure, an optical source and detector probes were attached to a DBT unit and, with the breast compressed, optical data was acquired. The optical probes were then removed without altering the breast compression and a DBT scan was performed.

"We are very excited about adding optical imaging to DBT, because it is low-cost, safe, noninvasive and fast," Dr. Fang said.

Of the 189 imaging studies, 138 were negative, and 51 showed evidence of lesions. As determined by breast biopsy, 26 lesions of the 51 lesions were malignant, and 25 were benign.

In the 26 malignant tumors, total hemoglobin concentration (HbT) was significantly greater than in the normal glandular tissue of the same breast. Solid benign lesions and cysts had significantly lower HbT contrast compared to the malignant lesions.

"By providing additional differentiation of malignant and benign lesions, combined optical and x-ray imaging could potentially reduce unnecessary biopsies," Dr. Fang said.

In the study, oxygen saturation levels were significantly lower in cysts compared to those in malignant and solid benign lesions and glandular breast tissue.

"Although cysts are easy to diagnose using ultrasound, distinguishing cysts from malignant or benign lesions during a mammogram would save women the anxiety and costs associated with a second procedure," Dr. Fang said. "We are hopeful that this combined system may help improve the efficiency and diagnostic accuracy of breast screening."

The study is part of an ongoing research effort to improve breast cancer diagnosis led by Daniel B. Kopans, M.D., and David Boas, Ph.D., and funded by the National Institutes of Health.

"Combined Optical and X-ray Tomosynthesis Breast Imaging." Collaborating with Dr. Fang were Juliette Selb, Ph.D., Stefan A. Carp, Ph.D., Greg Boverman, Ph.D., Eric L. Miller, Ph.D., Dana H. Brooks, Ph.D., Richard H. Moore, B.S., Daniel B. Kopans, M.D., and David A. Boas, Ph.D.

Radiology is edited by Herbert Y. Kressel, M.D., Harvard Medical School, Boston, Mass., and owned and published by the Radiological Society of North America, Inc. (http://radiology.rsna.org/)

RSNA is an association of more than 46,000 radiologists, radiation oncologists, medical physicists and related scientists committed to excellence in patient care through education and research. The Society is based in Oak Brook, Ill. (RSNA.org)

For patient-friendly information on breast imaging, visit RadiologyInfo.org.

Linda Brooks | EurekAlert!
Further information:
http://www.rsna.org

More articles from Medical Engineering:

nachricht Artificial intelligence may help diagnose tuberculosis in remote areas
25.04.2017 | Radiological Society of North America

nachricht Pharmacoscpy: Next-Generation Microscopy
25.04.2017 | CeMM Forschungszentrum für Molekulare Medizin der Österreichischen Akademie der Wissenschaften

All articles from Medical Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

Scientist invents way to trigger artificial photosynthesis to clean air

26.04.2017 | Materials Sciences

Ammonium nitrogen input increases the synthesis of anticarcinogenic compounds in broccoli

26.04.2017 | Agricultural and Forestry Science

SwRI-led team discovers lull in Mars' giant impact history

26.04.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>