Now researchers at the Royal Institute of Technology (KTH) in Stockholm have hit upon a new method that allows 5,000 samples to be run at the same time and at the same price. This cuts the cost per sample result considerably and constitutes a world record for the number of tests run in a single DNA sequencing analysis.
“We were virtually forced to invent a method for running numerous DNA tests at once. Otherwise our analyses would have taken an incredibly long time and would have cost enormous sums of money,” says Peter Savolainen, a researcher in biology at KTH.
He, his research colleague Afshin Ahmadian, and the then doctoral candidate Mårten Neiman jointly invented the new method, which means that DNA sequencing analyses can be performed both in record time and at an improbably low cost.
“Today the great majority of samples are run ten at a time. This yields a cost of SEK 10,000 (c. USD 1,600) per sample. We have run 5,000 samples at the same time at the same cost, that is, SEK 100,000. This computes to SEK 20 (c. USD 3) per sample,” says Peter Savolainen.
He points out several areas where his and his colleagues’ new method can have a great impact. One of them is cancer research, where there is a great need to scan numerous cell samples from many individuals. This is to see which cells and genes are involved in the cancer.
“Another field where our method can be of huge importance is in organ transplants. Many DNA analyses are needed to create a database for matching organ donors with transplant recipients. This will be of major importance to DNA research,” says Peter Savolainen.
He adds that now, even before the method is official, there are several projects at the Science for Life Laboratory (where KTH is involved) in line to use this mode of analysis. What’s more, it is possible to scale up the method so that even more samples can be tested simultaneously.
“Simply put, we mark each sample in an ingenious way with an ID, so each test result can be distinguished,” says Peter Savolainen.
Afshin Ahmadian and Peter Savolainen are KTH scientists who are active at the Science for Life Laboratory.
For more information, please contact Afshin Ahmadian at phone: +46 (0)8 – 524 81 450 / firstname.lastname@example.org or Peter Savolainen +46 (0)8 - 55 378 335 / email@example.com
Peter Larsson | idw
Not of Divided Mind
19.01.2017 | Hertie-Institut für klinische Hirnforschung (HIH)
CRISPR meets single-cell sequencing in new screening method
19.01.2017 | CeMM Forschungszentrum für Molekulare Medizin der Österreichischen Akademie der Wissenschaften
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
19.01.2017 | Earth Sciences
19.01.2017 | Life Sciences
19.01.2017 | Physics and Astronomy