Millions of Americans struggling with psoriasis and psoriatic arthritis are one step closer to a cure with the release of the first National Psoriasis Victor Henschel BioBank DNA samples for use in research at the University of Michigan Health System; research that hopes to uncover the unknowns about the genetics of psoriasis and psoriatic arthritis.
A disabling and disfiguring disease of the immune system that appears on the skin, psoriasis is the most common autoimmune disease in the country, affecting as many as 7.5 million Americans, yet it is one of the most under-researched. Up to 30 percent of people with psoriasis develop psoriatic arthritis, a related joint disease.
"Because we will be studying many thousands of genes, and because the genetic differences that predispose people to psoriasis can be subtle, this type of research requires thousands of cases and controls to yield statistically significant results," says James T. Elder, M.D., Ph.D., the Kirk D Wuepper Professor of Molecular Genetic Dermatology. "That's why the large number of Biobank samples is so important."
In the past few years, new discoveries into the hereditary factors of psoriasis have been unveiled. The National Psoriasis Victor Henschel BioBank is a collection of DNA samples and clinical information used by scientists to advance the field of psoriasis genetics--to fill the gap between what is known about psoriasis genetics and what's not.
Elder and his team of researchers received the first 1,250 BioBank DNA samples today. They will use the samples to identify new genes that increase a person's risk factor for developing psoriasis, and examine the connection between psoriasis and other autoimmune diseases, such as Crohn's disease, rheumatoid arthritis and lupus. Additional BioBank DNA samples will be given to Elder in the coming months.
"It's also very important that the diagnosis of psoriasis is definite, especially when it comes to psoriatic arthritis. The Biobank patients have all been carefully examined by dermatologists and rheumatologists, and provide an outstanding clinical resource," Elder adds.
The National Psoriasis Victor Henschel BioBank is a collection of DNA samples and clinical information used by scientists to advance the field of psoriasis genetics. Once completed, it will be the largest single collection of psoriasis DNA samples in the world.
"The BioBank is a critical resource for bringing us one step closer to a cure for psoriasis, and we are honored to partner with Dr. Elder and his team on this landmark project," says Rick Seiden, chair of the National Psoriasis Foundation Board of Trustees. "This endeavor would not be possible without the hundreds of people with and without psoriasis and psoriatic arthritis who donated DNA over the past four years, and we thank all of them for their huge contribution to psoriasis research."
The National Psoriasis Foundation created the BioBank in honor of Victor Henschel, a highly revered member of the psoriasis community who lived with psoriasis and psoriatic arthritis for 35 years. The Henschel family, many of whom also live with psoriatic disease, donated money to the Foundation to start the BioBank.
Research to be performed on the Biobank samples at U-M is being funded by the National Institutes of Health. Results obtained using the Biobank samples will be rapidly made available to the scientific community.
Multi-institutional collaboration uncovers how molecular machines assemble
02.12.2016 | Salk Institute
Fertilized egg cells trigger and monitor loss of sperm’s epigenetic memory
02.12.2016 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water
In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...
The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.
Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
02.12.2016 | Medical Engineering
02.12.2016 | Agricultural and Forestry Science
02.12.2016 | Physics and Astronomy