Millions of Americans struggling with psoriasis and psoriatic arthritis are one step closer to a cure with the release of the first National Psoriasis Victor Henschel BioBank DNA samples for use in research at the University of Michigan Health System; research that hopes to uncover the unknowns about the genetics of psoriasis and psoriatic arthritis.
A disabling and disfiguring disease of the immune system that appears on the skin, psoriasis is the most common autoimmune disease in the country, affecting as many as 7.5 million Americans, yet it is one of the most under-researched. Up to 30 percent of people with psoriasis develop psoriatic arthritis, a related joint disease.
"Because we will be studying many thousands of genes, and because the genetic differences that predispose people to psoriasis can be subtle, this type of research requires thousands of cases and controls to yield statistically significant results," says James T. Elder, M.D., Ph.D., the Kirk D Wuepper Professor of Molecular Genetic Dermatology. "That's why the large number of Biobank samples is so important."
In the past few years, new discoveries into the hereditary factors of psoriasis have been unveiled. The National Psoriasis Victor Henschel BioBank is a collection of DNA samples and clinical information used by scientists to advance the field of psoriasis genetics--to fill the gap between what is known about psoriasis genetics and what's not.
Elder and his team of researchers received the first 1,250 BioBank DNA samples today. They will use the samples to identify new genes that increase a person's risk factor for developing psoriasis, and examine the connection between psoriasis and other autoimmune diseases, such as Crohn's disease, rheumatoid arthritis and lupus. Additional BioBank DNA samples will be given to Elder in the coming months.
"It's also very important that the diagnosis of psoriasis is definite, especially when it comes to psoriatic arthritis. The Biobank patients have all been carefully examined by dermatologists and rheumatologists, and provide an outstanding clinical resource," Elder adds.
The National Psoriasis Victor Henschel BioBank is a collection of DNA samples and clinical information used by scientists to advance the field of psoriasis genetics. Once completed, it will be the largest single collection of psoriasis DNA samples in the world.
"The BioBank is a critical resource for bringing us one step closer to a cure for psoriasis, and we are honored to partner with Dr. Elder and his team on this landmark project," says Rick Seiden, chair of the National Psoriasis Foundation Board of Trustees. "This endeavor would not be possible without the hundreds of people with and without psoriasis and psoriatic arthritis who donated DNA over the past four years, and we thank all of them for their huge contribution to psoriasis research."
The National Psoriasis Foundation created the BioBank in honor of Victor Henschel, a highly revered member of the psoriasis community who lived with psoriasis and psoriatic arthritis for 35 years. The Henschel family, many of whom also live with psoriatic disease, donated money to the Foundation to start the BioBank.
Research to be performed on the Biobank samples at U-M is being funded by the National Institutes of Health. Results obtained using the Biobank samples will be rapidly made available to the scientific community.
Complementing conventional antibiotics
24.05.2018 | Goethe-Universität Frankfurt am Main
Building a brain, cell by cell: Researchers make a mini neuron network (of two)
23.05.2018 | Institute of Industrial Science, The University of Tokyo
A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.
The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
24.05.2018 | Ecology, The Environment and Conservation
24.05.2018 | Medical Engineering
24.05.2018 | Physics and Astronomy