Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

U of M researcher helps unlock 30 new genes responsible for early-onset puberty

02.12.2010
University of Minnesota School of Public Health researcher Ellen Demerath, Ph.D., is among an international group of researchers that has identified 30 new genes responsible for determining the age of sexual maturation in women.

Many of these genes are also known to influence body fatness, obesity, and energy metabolism. Prior to the multi-institutional study, only four genes had been identified as contributing to the process.

The findings, which were reported in Nature Genetics, help to explain why girls who are obese tend to have earlier puberty: some of the same genes are involved in both outcomes. Early menarche, or the first menstrual cycle, is linked to a variety of chronic adulthood diseases, including breast cancer, cardiovascular diseases, and type 2 diabetes.

As a result of these discoveries, Demerath suggests that health care providers and other professionals pay particularly close attention to girls with a high risk of obesity (those who are overweight in childhood or who have a parental history of obesity) and intervene with them, as those girls are also genetically more susceptible to early menarche.

“Early menarche is caused by both genetics and environmental factors,” said Demerath. “We already knew that diet and physical exercise play a role in menarche, but now that we’ve identified more of the specific genes involved, this gives us clues about how to intervene on the process. By showing how hereditary and biological factors contribute to early menarche, we hope to one day allow health care providers to identify girls with increased risk of early menarche, and help them avoid the complications of early-onset puberty.”

In the large-scale, NIH-funded study, researchers from 104 institutions collected data from more than 100,000 women from the United States, Europe, and Australia. This includes women from the Twin Cities area enrolled in the Atherosclerosis Risk in Communities (ARIC) study. Not only were researchers able to identify these new genes, but they also found that many of them play a role in body weight regulation or biological pathways related to fat metabolism. The study findings also suggest that menarche is a result of a complex range of biological processes.

Today, girls are menstruating earlier than ever before. In the mid-1900s, the average age of menarche was 14-15 years. The average age today is 12-13 years.

“We now know that hormone regulation, cell development, and other mechanisms are related to menarche,” said Demerath.

According to Demerath, the next step for researchers is to examine whether some of these genes also influence sexual development in males, whether the genes are related to general growth in size as well as development, the points in the life cycle when the genes are most powerfully expressed, and how environmental factors such as diet and physical activity can modify their effects.

School of Public Health
For more than 60 years, the University of Minnesota School of Public Health has been among the top accredited schools of public health in the nation. With a mission focused on research, teaching, and service, the school attracts nearly $100 million in research funding each year, has more than 100 faculty members and more than 1,300 students, and is engaged in community outreach activities locally, nationally and in dozens of countries worldwide. For more information, visit www.sph.umn.edu.
Emily Jensen
Academic Health Center
612-624-9163
jense888@umn.edu
Kris Stouffer
School of Public Health
612-624-4460
stouffer@umn.edu

Emily Jensen | EurekAlert!
Further information:
http://www.umn.edu

More articles from Life Sciences:

nachricht New risk factors for anxiety disorders
24.02.2017 | Julius-Maximilians-Universität Würzburg

nachricht Stingless bees have their nests protected by soldiers
24.02.2017 | Johannes Gutenberg-Universität Mainz

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>