In first-aid situations, wounds must be quickly and effectively closed to stop blood loss and prevent infection. For treatment on arrival in a hospital, the temporary seal must be reopened, which often causes additional damage to the injured tissue. In the journal Angewandte Chemie, American scientists have now introduced a novel gel for sealing wounds. The gel can later be dissolved and gently removed.
Injuries sustained in remote areas, far from civilization, or in military action can often not be treated in a clinic until hours later. In such scenarios, a temporary wound closure system is desirable. Such a system should: 1) stop the bleeding for several hours, 2) adhere to the tissue, 3) be easy to apply, and 4) be easily removable in a controlled manner to make the wound accessible during surgical treatment. No single wound-closure systems currently available meet all of these requirements. Removal of blood-clotting agents or dressings requires tearing or surgical excision, both of which can increase the size of the wound and make it worse.
Scientists working at Boston University and the Beth Israel Deaconess Medical Center in Boston have now developed a wound-closure system based on a synthetic biocompatible gel that meets the requirements listed above. The gel is cross-linked through branched thioesters. The team, led by Mark W. Grinstaff, uses a chemical reaction known as thiol–thioester exchange in order to dissolve these gels for removal.
In this reaction, a thioester bond reacts with a thiolate anion to produce new thioester and thiolate products. The advantage of this reaction is that it takes place in an aqueous environment under physiological conditions. This type of reaction also occurs in natural biological processes. When the thioester gel is treated with cysteine methyl ester, the thioester bridges are rapidly split and the gel dissolves.
Wounds may be treated by simply mixing and applying two starting materials. The gel forms within seconds, adheres to the skin even when stress is applied and remains intact for several days. The gel absorbs any liquid exiting the wound. Treatment with cysteine methyl ester causes the wound closure to reopen within 30 minutes. To simulate injury to a vein, the researchers filled a section of bovine jugular vein with buffer solution and punctured it. Once the gel was applied, the damaged vein was completely sealed; after dissolution of the gel, the buffer solution flowed out again.About the Author
Angewandte Chemie International Edition, Permalink to the article: http://dx.doi.org/10.1002/anie.201308007
Mark W. Grinstaff | Angewandte Chemie
A Map of the Cell’s Power Station
18.08.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau
On the way to developing a new active ingredient against chronic infections
18.08.2017 | Deutsches Zentrum für Infektionsforschung
Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
16.08.2017 | Event News
04.08.2017 | Event News
26.07.2017 | Event News
18.08.2017 | Life Sciences
18.08.2017 | Physics and Astronomy
18.08.2017 | Materials Sciences