The team, whose principal investigators include Gregory Frolenkov of the UK Department of Physiology, developed “hopping probe ion conductance microscopy,” in which a nanoscale probe “hops” over the surface of a cell in an action similar to a sewing machine needle. They published their development in this week’s edition of Nature Methods.
The technique permitted the researchers to visualize the surface of a complex living cell at a nanoscale resolution, which was previously possible only in dead cells using electron microscopy.
“Now we can see nanostructures such as individual protein or protein complexes in a living cell and probe their function. Many diseases affect the cell surface.
Therefore, we expect that our technique, together with emerging high-resolution imaging techniques looking inside the cell, will clarify the mechanisms of a number of diseases, the same way as a regular optical microscope revolutionized medicine centuries ago,” Frolenkov said.
The other co-principal investigators on the project are Yuri E. Korchev of the Imperial College London Division of Medicine in London, United Kingdom, and David Klenerman of Cambridge University’s Department of Chemistry in Cambridge, United Kingdom. Also participating in the research was Ruben Stepanyan of the UK Department of Physiology, part of the UK College of Medicine.
Newly designed molecule binds nitrogen
23.02.2018 | Julius-Maximilians-Universität Würzburg
Atomic Design by Water
23.02.2018 | Max-Planck-Institut für Eisenforschung GmbH
A newly developed laser technology has enabled physicists in the Laboratory for Attosecond Physics (jointly run by LMU Munich and the Max Planck Institute of Quantum Optics) to generate attosecond bursts of high-energy photons of unprecedented intensity. This has made it possible to observe the interaction of multiple photons in a single such pulse with electrons in the inner orbital shell of an atom.
In order to observe the ultrafast electron motion in the inner shells of atoms with short light pulses, the pulses must not only be ultrashort, but very...
A group of researchers led by Andrea Cavalleri at the Max Planck Institute for Structure and Dynamics of Matter (MPSD) in Hamburg has demonstrated a new method enabling precise measurements of the interatomic forces that hold crystalline solids together. The paper Probing the Interatomic Potential of Solids by Strong-Field Nonlinear Phononics, published online in Nature, explains how a terahertz-frequency laser pulse can drive very large deformations of the crystal.
By measuring the highly unusual atomic trajectories under extreme electromagnetic transients, the MPSD group could reconstruct how rigid the atomic bonds are...
Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
23.02.2018 | Physics and Astronomy
23.02.2018 | Health and Medicine
23.02.2018 | Physics and Astronomy