The team, whose principal investigators include Gregory Frolenkov of the UK Department of Physiology, developed “hopping probe ion conductance microscopy,” in which a nanoscale probe “hops” over the surface of a cell in an action similar to a sewing machine needle. They published their development in this week’s edition of Nature Methods.
The technique permitted the researchers to visualize the surface of a complex living cell at a nanoscale resolution, which was previously possible only in dead cells using electron microscopy.
“Now we can see nanostructures such as individual protein or protein complexes in a living cell and probe their function. Many diseases affect the cell surface.
Therefore, we expect that our technique, together with emerging high-resolution imaging techniques looking inside the cell, will clarify the mechanisms of a number of diseases, the same way as a regular optical microscope revolutionized medicine centuries ago,” Frolenkov said.
The other co-principal investigators on the project are Yuri E. Korchev of the Imperial College London Division of Medicine in London, United Kingdom, and David Klenerman of Cambridge University’s Department of Chemistry in Cambridge, United Kingdom. Also participating in the research was Ruben Stepanyan of the UK Department of Physiology, part of the UK College of Medicine.
Toward a 'smart' patch that automatically delivers insulin when needed
18.01.2017 | American Chemical Society
127 at one blow...
18.01.2017 | Stiftung Zoologisches Forschungsmuseum Alexander Koenig, Leibniz-Institut für Biodiversität der Tiere
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).
Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...
10.01.2017 | Event News
09.01.2017 | Event News
05.01.2017 | Event News
18.01.2017 | Power and Electrical Engineering
18.01.2017 | Materials Sciences
18.01.2017 | Life Sciences