Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers find key step in body's ability to make red blood cells

02.08.2010
Researchers at UT Southwestern Medical Center have uncovered a key step in the creation of new red blood cells in an animal study.

They found that a tiny fragment of ribonucleic acid (RNA), a chemical cousin of DNA, prompts stem cells to mature into red blood cells. The researchers also created an artificial RNA inhibitor to block this process.

Such interventions, if fruitful in humans, might be useful against some cancers and other diseases, such as polycythemia vera, in which the body produces a life-threatening excess of blood cells. Conversely, a drug that boosts red blood cell production might be useful against anemia, blood loss or altitude sickness.

"The important finding is that this microRNA, miR-451, is a powerful natural regulator of red blood cell production," said Dr. Eric Olson, chairman of molecular biology at UT Southwestern and senior author of the study, which appears in the Aug. 1 issue of Genes & Development.

"We also showed that a man-made miR-451 inhibitor can reduce miR-451 levels in a mouse and block blood-cell production. We hope that this inhibitor and similarly functioning molecules might lead to new drugs against the fatal disease polycythemia vera, which currently has no therapies," said Dr. Olson, who directs the Nancy B. and Jake L. Hamon Center for Basic Research in Cancer and the Nearburg Family Center for Basic and Clinical Research in Pediatric Oncology.

Red blood cells, which carry oxygen throughout the body, are created in bone marrow from stem cells. The body steps up its production of red blood cells in response to stresses such as anemia, blood loss or low oxygen, but overproduction of the cells increases the risk of stroke and blood clots.

RNA molecules, found throughout cells, perform several jobs. MicroRNAs often bind to and disable other types of RNA, preventing them from carrying out their functions.

Dr. Olson and his colleagues study many different types of microRNAs to determine their functions and to find therapeutic uses of artificial microRNAs.

"miR-451 is found in great abundance in mature red blood cells, but its function was not known," said lead author David Patrick, a graduate student in molecular biology.

In the new study, the scientists created genetically engineered mice that could not make miR-451. The mice had a lowered red blood cell count and also had difficulty creating more red blood cells under conditions that usually stimulate production.

miR-451 works by interacting with another RNA involved in producing a protein called 14-3-3-zeta, which plays a role in the maturation of many types of cells, the researchers found.

The team also treated blood stem cells with an artificial RNA designed to inhibit miR-451. As a result, the number of red blood cells decreased.

Dr. Olson and his colleagues are pursuing a patent on miR-451 inhibitors and studying whether a microRNA-based drug might be useful in treating several blood-related disorders.

Other UT Southwestern researchers involved in the study were Dr. Cheng Zhang, assistant professor of physiology and developmental biology; Xiaoxia Qi, research scientist in molecular biology; and Dr. Lily Jun-Shen Huang, assistant professor of cell biology. Researchers from Texas A&M Health Science Center, Houston; Texas Heart Institute, Houston; and the University of Houston also participated.

The study was funded by the National Institutes of Health, the Welch Foundation and the American Heart Association – Jon Holden DeHaan Foundation.

This news release is available on our World Wide Web home page at http://www.utsouthwestern.edu/home/news/index.html

To automatically receive news releases from UT Southwestern via e-mail, subscribe at www.utsouthwestern.edu/receivenews

Aline McKenzie | EurekAlert!
Further information:
http://www.utsouthwestern.edu

Further reports about: Foundation Heart Olson RNA RNA molecule blood cell health services red blood cells stem cells

More articles from Life Sciences:

nachricht Symbiotic bacteria: from hitchhiker to beetle bodyguard
28.04.2017 | Johannes Gutenberg-Universität Mainz

nachricht Nose2Brain – Better Therapy for Multiple Sclerosis
28.04.2017 | Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik IGB

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Fighting drug resistant tuberculosis – InfectoGnostics meets MYCO-NET² partners in Peru

28.04.2017 | Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

 
Latest News

Wireless power can drive tiny electronic devices in the GI tract

28.04.2017 | Medical Engineering

Ice cave in Transylvania yields window into region's past

28.04.2017 | Earth Sciences

Nose2Brain – Better Therapy for Multiple Sclerosis

28.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>