Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers discover 3 genes that increase risk of severe obesity in kids and adults

21.01.2009
McGill scientists play key role in international genome-wide association study

European and Canadian researchers have, for the first time, drawn a map of genetic risk factors that can lead to two forms of severe obesity: early-onset obesity in children, and morbid obesity in adults.

A genetic study of 1,380 Europeans with early-onset and morbid adult obesity was led by French researchers Dr. David Meyre, of the Institut national de la santé et de la recherche médicale (Inserm), and Dr. Philippe Froguel, director of the Centre National de la Recherche Scientifique (CNRS). Dr. Rob Sladek, Dr. Constantin Polychronakos and Dr. Alexandre Montpetit, of McGill University and the McGill University and Génome Québec Innovation Centre, made key contributions to the discovery, along with researchers from France, Britain, Finland, Switzerland and Germany.

The results were published Jan. 19 in the journal Nature Genetics. Finding the genetic cause of a medical problem can often lead researchers along the right path toward an eventual treatment or cure or to help identify people who might be at risk.

"The idea was not just to look at run-of-the-mill obesity, but look for genetic factors that may affect people who have more severe problems with their weight," said Dr. Sladek, an assistant professor in the Department of Human Genetics and Endocrinology. "This includes children who become obese at a young age, before the age of six. We also studied the genomes of adults who had a familial history of severe obesity, with a body-mass index greater than 40." People are generally defined as "overweight" if they have a body-mass index greater than 25.

"The family approach being undertaken by our collaboration with our colleagues in France is going to become important for future large-scale genetic studies," Sladek continued. "Our suspicion is that a lot of the genetic changes that make people obese will turn out to be variants that run in families or in segments of the population, rather than things that are very common across the population. In terms of diabetes, we think that perhaps 90 per cent of the genetic risk could come from these familial or even personal genetic variants."

"We are proud of this announcement, which once again confirms the scientific excellence and talent of Québec's scientists," said Paul L'Archevêque, President and CEO of Génome Québec. "These findings, which are the direct result of studies co-financed by Génome Québec, clearly show the strategic role of genomics in the search for solutions to improve human health. We would also like to underline the cooperation among the institutes, an initiative that made this major advance possible. Congratulations to the McGill University and Génome Québec Innovation Centre team, and especially to Alexandre Montpetit who trained a group from CNRS on genotyping data analysis on the Illumina platform."

Mark Shainblum | EurekAlert!
Further information:
http://www.mcgill.ca

More articles from Life Sciences:

nachricht Rutgers scientists discover 'Legos of life'
23.01.2018 | Rutgers University

nachricht Researchers identify a protein that keeps metastatic breast cancer cells dormant
23.01.2018 | Institute for Research in Biomedicine (IRB Barcelona)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Optical Nanoscope Allows Imaging of Quantum Dots

Physicists have developed a technique based on optical microscopy that can be used to create images of atoms on the nanoscale. In particular, the new method allows the imaging of quantum dots in a semiconductor chip. Together with colleagues from the University of Bochum, scientists from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute reported the findings in the journal Nature Photonics.

Microscopes allow us to see structures that are otherwise invisible to the human eye. However, conventional optical microscopes cannot be used to image...

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Rutgers scientists discover 'Legos of life'

23.01.2018 | Life Sciences

Seabed mining could destroy ecosystems

23.01.2018 | Earth Sciences

Transportable laser

23.01.2018 | Physics and Astronomy

VideoLinks Science & Research
Overview of more VideoLinks >>>