Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers discover 3 genes that increase risk of severe obesity in kids and adults

21.01.2009
McGill scientists play key role in international genome-wide association study

European and Canadian researchers have, for the first time, drawn a map of genetic risk factors that can lead to two forms of severe obesity: early-onset obesity in children, and morbid obesity in adults.

A genetic study of 1,380 Europeans with early-onset and morbid adult obesity was led by French researchers Dr. David Meyre, of the Institut national de la santé et de la recherche médicale (Inserm), and Dr. Philippe Froguel, director of the Centre National de la Recherche Scientifique (CNRS). Dr. Rob Sladek, Dr. Constantin Polychronakos and Dr. Alexandre Montpetit, of McGill University and the McGill University and Génome Québec Innovation Centre, made key contributions to the discovery, along with researchers from France, Britain, Finland, Switzerland and Germany.

The results were published Jan. 19 in the journal Nature Genetics. Finding the genetic cause of a medical problem can often lead researchers along the right path toward an eventual treatment or cure or to help identify people who might be at risk.

"The idea was not just to look at run-of-the-mill obesity, but look for genetic factors that may affect people who have more severe problems with their weight," said Dr. Sladek, an assistant professor in the Department of Human Genetics and Endocrinology. "This includes children who become obese at a young age, before the age of six. We also studied the genomes of adults who had a familial history of severe obesity, with a body-mass index greater than 40." People are generally defined as "overweight" if they have a body-mass index greater than 25.

"The family approach being undertaken by our collaboration with our colleagues in France is going to become important for future large-scale genetic studies," Sladek continued. "Our suspicion is that a lot of the genetic changes that make people obese will turn out to be variants that run in families or in segments of the population, rather than things that are very common across the population. In terms of diabetes, we think that perhaps 90 per cent of the genetic risk could come from these familial or even personal genetic variants."

"We are proud of this announcement, which once again confirms the scientific excellence and talent of Québec's scientists," said Paul L'Archevêque, President and CEO of Génome Québec. "These findings, which are the direct result of studies co-financed by Génome Québec, clearly show the strategic role of genomics in the search for solutions to improve human health. We would also like to underline the cooperation among the institutes, an initiative that made this major advance possible. Congratulations to the McGill University and Génome Québec Innovation Centre team, and especially to Alexandre Montpetit who trained a group from CNRS on genotyping data analysis on the Illumina platform."

Mark Shainblum | EurekAlert!
Further information:
http://www.mcgill.ca

More articles from Life Sciences:

nachricht Programming cells with computer-like logic
27.07.2017 | Wyss Institute for Biologically Inspired Engineering at Harvard

nachricht Identified the component that allows a lethal bacteria to spread resistance to antibiotics
27.07.2017 | Institute for Research in Biomedicine (IRB Barcelona)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Physicists Design Ultrafocused Pulses

Physicists working with researcher Oriol Romero-Isart devised a new simple scheme to theoretically generate arbitrarily short and focused electromagnetic fields. This new tool could be used for precise sensing and in microscopy.

Microwaves, heat radiation, light and X-radiation are examples for electromagnetic waves. Many applications require to focus the electromagnetic fields to...

Im Focus: Carbon Nanotubes Turn Electrical Current into Light-emitting Quasi-particles

Strong light-matter coupling in these semiconducting tubes may hold the key to electrically pumped lasers

Light-matter quasi-particles can be generated electrically in semiconducting carbon nanotubes. Material scientists and physicists from Heidelberg University...

Im Focus: Flexible proximity sensor creates smart surfaces

Fraunhofer IPA has developed a proximity sensor made from silicone and carbon nanotubes (CNT) which detects objects and determines their position. The materials and printing process used mean that the sensor is extremely flexible, economical and can be used for large surfaces. Industry and research partners can use and further develop this innovation straight away.

At first glance, the proximity sensor appears to be nothing special: a thin, elastic layer of silicone onto which black square surfaces are printed, but these...

Im Focus: 3-D scanning with water

3-D shape acquisition using water displacement as the shape sensor for the reconstruction of complex objects

A global team of computer scientists and engineers have developed an innovative technique that more completely reconstructs challenging 3D objects. An ancient...

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

 
Latest News

Programming cells with computer-like logic

27.07.2017 | Life Sciences

Identified the component that allows a lethal bacteria to spread resistance to antibiotics

27.07.2017 | Life Sciences

Malaria Already Endemic in the Mediterranean by the Roman Period

27.07.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>