A structural biologist at the Florida State University College of Medicine has made discoveries that could lead scientists a step closer to understanding how life first emerged on Earth billions of years ago.
Professor Michael Blaber and his team produced data supporting the idea that 10 amino acids believed to exist on Earth around 4 billion years ago were capable of forming foldable proteins in a high-salt (halophile) environment. Such proteins would have been capable of providing metabolic activity for the first living organisms to emerge on the planet between 3.5 and 3.9 billion years ago.
The results of Blaber’s three-year study, which was built around investigative techniques that took more than 17 years to develop, are published in the journal Proceedings of the National Academy of Sciences.
The first living organisms would have been microscopic, cell-like organizations capable of replicating and adapting to environmental conditions — a humble beginning to life on Earth.
“The current paradigm on the emergence of life is that RNA came first and in a high-temperature environment,” Blaber said. “The data we are generating are much more in favor of a protein-first view in a halophile environment.”
The widely accepted view among scientists is that RNA, found in all living cells, would have likely represented the first molecules of life, hypothesizing an “RNA-first” view of the origin of living systems from non-living molecules. Blaber’s results indicate that the set of amino acids produced by simple chemical processes contains the requisite information to produce complex folded proteins, which supports an opposing “protein-first” view.
“The halophile, or salt-loving, environment has typically been considered one that life adapted into, not started in,” Blaber said. “Our study of the prebiotic amino acids and protein design and folding suggests the opposite.”
Without the ability to fold, proteins would not be able to form the precise structures essential for functions that sustain life as we know it. Folding allows proteins to take on a globular shape through which they can interact with other proteins, perform specific chemical reactions, and adapt to enable organisms to exploit a given environment.
“There are numerous niches that life can evolve into,” Blaber said. “For example, extremophiles are organisms that exist in high temperatures, high acidity, extreme cold, extreme pressure and extreme salt and so on. For life to exist in such environments it is essential that proteins are able to adapt in those conditions. In other words, they have to be able to fold.”
Comet and meteorite fragments, like those that recently struck in the Urals region of Russia, have provided evidence regarding the arrival of amino acids on Earth. Such fragments predate the earth and would have been responsible for delivering a set of 10 prebiotic (before life) amino acids, whose origins are in the formation of our solar system.
Today the human body uses 20 common amino acids to make all its proteins. Ten of those emerged through biosynthetic pathways — the way living systems evolve. Ten — the prebiotic set — can be made by chemical reactions without requiring any living system or biosynthetic pathway.
Scientific evidence exists to support many elements in theories of abiogenesis (the emergence of life), including the time frame (around 3.5 to 3.9 billion years ago) and the conditions on Earth and in its atmosphere at that time. Earth would have been made up of volcanic land masses (the beginning of the formation of continents), salty oceans and fresh-water ponds, along with a hot (around 80 degrees Celsius) and steamy atmosphere comprising carbon dioxide and nitrogen. Oxygen would have come later as a by-product of green plant life and bacteria that emerged.
Using a technique called top-down symmetric deconstruction, Blaber’s lab has been able to identify small peptide building blocks capable of spontaneous assembly into specific and complex protein architectures. His recent work explored whether such building blocks can be comprised of only the 10 prebiotic amino acids and still fold.
His team has achieved foldability in proteins down to 12 amino acids — about 80 percent of the way to proving his hypothesis.
If Blaber’s theory holds, scientists may refocus where they look for evidence in the quest to understand where, and how, life began.
“Rather than a curious niche that life evolved into, the halophile environment now may take center stage as the likely location for key aspects of abiogenesis,” he said.
“Likewise, the role of the formation of proteins takes on additional importance in the earliest steps in the beginnings of life on Earth.”
Co-authors on the PNAS paper are Liam M. Longo, an FSU graduate student, and Jihun Lee, a former postdoctoral researcher now at the National Institutes of Health.
Doug Carlson | Newswise
20.11.2017 | Washington University in St. Louis
Carefully crafted light pulses control neuron activity
20.11.2017 | University of Illinois at Urbana-Champaign
The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.
Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...
Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.
That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...
Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.
During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....
The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.
Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...
Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...
15.11.2017 | Event News
15.11.2017 | Event News
30.10.2017 | Event News
20.11.2017 | Life Sciences
20.11.2017 | Materials Sciences
20.11.2017 | Life Sciences