Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

'Fingerprints' help find genes involved in differentiation

19.11.2007
A database that includes the molecular profiles of the major components of the blood system – including the stem cells and the cells differentiated from them – enabled researchers at Baylor College of Medicine (BCM) in Houston to identify at least two genes involved in the differentiation process for two different kinds of blood cells.

In a report that appears in the journal Cell Stem Cell today, Dr. Margaret A. Goodell, professor of pediatrics and director of BCM’s STem Cells and Regeneration Center (STaR), and her colleagues described how they used their database to determine what was unique to each blood cell and what was common to all the cell types.

Understanding differentiation and what signals cause the early or progenitor cells to become the more specialized tissues that make multicellular organisms – such as mammals – possible is of vital concern to scientists and particularly stem cell biologists.

In this case, the scientists identified between 100 and 400 genes uniquely expressed in each cell type and termed these “lineage fingerprints,” because they mark the different cells that arise from the various stem cells.

... more about:
»Differentiation »blood »genes

“With unique genes, some will be responsible for generating those cell types,” said Goodell. She and her colleagues caused two of the genes (Zfp105 from the natural killer or NK cell lineage, and Ets2 from the monocyte (white blood cells with a singe nucleus that surround and ingest foreign materials) lineage to overexpress or make more than usual amounts of protein.

“They ended up driving differentiation,” said Goodell. That means that genes encouraged progenitor or early forms of the cells to become the mature or final blood cells that carry out specific tasks in the blood system.

“We are hoping that if we screen more of these genes that we can identify others that cause differentiation,” she said.

In the future, she said, scientists might consider ways to use the genes to help generate the differentiated cells in the laboratory as a particular form of treatment or developing drugs to block the action of the genes. Overproduction of certain blood or immune system cells can lead to cancer or autoimmune disease.

The three-year study involved considerable teamwork, said Goodell, with individuals in the lab taking responsibility for studies involving the different populations of blood cells.

Kimberlee Barbour | EurekAlert!
Further information:
http://www.bcm.edu
http://www.cellstemcell.com/

Further reports about: Differentiation blood genes

More articles from Life Sciences:

nachricht Researchers develop eco-friendly, 4-in-1 catalyst
25.04.2017 | Brown University

nachricht Transfecting cells gently – the LZH presents a GNOME prototype at the Labvolution 2017
25.04.2017 | Laser Zentrum Hannover e.V.

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

NASA's Fermi catches gamma-ray flashes from tropical storms

25.04.2017 | Physics and Astronomy

Researchers invent process to make sustainable rubber, plastics

25.04.2017 | Materials Sciences

Transfecting cells gently – the LZH presents a GNOME prototype at the Labvolution 2017

25.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>