Glutamate is one of the most common neurotransmitters in the human brain and is involved in virtually all brain functions. But even though researchers' PET cameras can produce images of other important neurotransmission systems, such as the dopamine and serotonin systems, until now it has not been possible to capture images of the glutamate system. This is because there has not been any suitable tracer that can bind specifically to the receptors in the glutamate system.
In collaboration with Karolinska Institutet, AstraZeneca has now developed such a tracer, which makes it possible for the first time to study the glutamate system in the brains of living people.
"The glutamate system is an area of keen interest for research, especially for gaining an understanding of neuropsychiatric disorders," says Professor Lars Farde at Karolinska Institutet and AstraZeneca. "All anti-psychotic medicines currently available on the market work via the dopamine system, for example. However, it may well turn out that glutamate receptors are even better drug targets."
Within the framework of this same collaboration, a state-of-the-art PET camera has been purchased for use in both academic research and pharmaceutical development.
"The new PET camera will allow us to study the brain with a much higher richness of detail than previously," comments Professor Christer Halldin of Karolinska Institutet. "And thanks to the new tracer, we will be able to explore an entirely new neurotransmission system through high-resolution imaging."
Sabina Bossi | alfa
Cells communicate in a dynamic code
19.02.2018 | California Institute of Technology
Studying mitosis' structure to understand the inside of cancer cells
19.02.2018 | Biophysical Society
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.
But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...
Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.
The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...
Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters
Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
19.02.2018 | Materials Sciences
19.02.2018 | Materials Sciences
19.02.2018 | Life Sciences