The study will be published in the Journal of Neuroscience (February 28, 2007 issue). They had opportunity to determine activity-dependent plasticity – a cellular process, in which the connections between individual brain cells get stronger the more often they are used, such as during learning - in the hippocampus of freely moving mouse mutants. Recording in vivo techniques were developed last year by the group of Drs. J.M. Delgado-García and A. Gruart (see Gruart et al., 26: 1077-1087, 2006), and allow determining the explicit relation between the learning process and the physiological synaptic enhancement in the hippocampus.
Neurotrophins and their receptors might serve as feedback regulators for the efficacy of synaptic transmission. As recently shown in vivo by some of us, the BDNF-TrkB system is well known for its importance in synaptic plasticity and long-term potentiation (LTP) in the hippocampus (see Gruart et al., Learn. Mem., 4: 54-62, 2007). However, until now, the role of other neurotrophin systems in mediating synaptic modulation remained to be elucidated. In their study, the groups of Drs. M. Dierssen, and J.M. Delgado-García and A. Gruart used transgenic mice overexpressing TrkC to test the hypothesis that in vivo overexpression of the TrkC receptor could produce an increase in survival and/or neuronal induction or promotion in the hippocampus, with some putative consequences for learning and synaptic plasticity in adult mice. In their experiments, the activity-dependent strength of the hippocampal CA3-CA1 synapse –a brain region involved in learning- was recorded in behaving mice, while animals were being trained to the classical conditioning of eyelid responses.
For the first time, the work clearly provides evidence for a direct, causal role for the NT-3-TrkC cascade in the physiological potentiation of field excitatory post-synaptic potentials (fEPSP) evoked at the CA3-CA1 synapse during the acquisition of an associative learning task, as well as in early and late maintenance of experimentally induced LTP. Interestingly, overexpression of TrkC seems to reduce the efficiency of conditioned learning, an effect that has previously been observed after LTP ‘saturation’ induced experimentally in behaving mice (Gruart et al., 26: 1077-1087, 2006). It is thus possible that TrkC overexpression enhances too much hippocampal synaptic activity, which then occludes normal associative learning.
This paper shows for the first time the dissociation between the ability to learn a task and the changes in synaptic plasticity seen during synaptic potentiation in behaving mice and suggests that it is the combination of different neurotrophin systems what leads to the proper balance of learning abilities in mammals.
Gloria Lligadas | alfa
North and South Cooperation to Combat Tuberculosis
22.03.2018 | Universität Zürich
Researchers Discover New Anti-Cancer Protein
22.03.2018 | Universität Basel
An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.
The incidence of liver cancer, also known as hepatocellular carcinoma, is steadily increasing. In the last twenty years, the number of cases has almost doubled...
In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.
Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...
Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.
They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...
A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...
For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.
In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...
19.03.2018 | Event News
16.03.2018 | Event News
13.03.2018 | Event News
22.03.2018 | Trade Fair News
22.03.2018 | Earth Sciences
22.03.2018 | Earth Sciences