It is expected the participation of the following guest speakers: Peer Bork, from EMBL in Heidelberg (Germany); Timothy Gardner, from the Boston University (USA); Mads Kaern, from the University of Ottawa (Canada); Nadav Kashtan, from the Weizmann Institute of Science in Rehovot (Israel); Patrick Lemaire, from the Developmental Biology Institute of Marseilles-Luminy (France); Martin Lercher, from the University of Bath (United Kingdom); Alfonso Martínez-Arias, from the University of Cambridge (United Kingdom); Uwe Sauer, from the Institute for Molecular Systems Biology-ETH in Zurich (Switzerland); Ricard V. Solé, from the Universitat Pompeu Fabra in Barcelona (Spain); Marc Vidal, from the Dana-Farber Institute in Boston (USA); Ron Weiss, from Princeton University (USA); Mark Isalan and James Sharpe, both from the Centre for Genomic Regulation in Barcelona (Spain).
Systems Biology is an emerging discipline that aims at a quantitative understanding of biological systems to an extent that one is able to predict its response to external (drugs) or internal (mutations) disturbances and, in the future, even to modify them rationally (Synthetic Biology). The most obvious applications of Systems Biology are in the field of medicine. At the moment, the way medicine works is by using very similar drugs and treatments for everyone. We are all aware of the multibillion losses that pharmaceutical companies have suffered in the last years due to the commercialization of drugs that, although beneficial for a large part of the population are harmful for certain groups of people. Treatment of diseases today remains still to a large extent the same as when aspirin was discovered. Essentially either serendipitously or through the identification of putative targets in basic research a massive screening is done helped or lead by design software, and candidate drugs are then tested on different systems to assess their toxicity and potency. Drugs that pass this stage are then validated by very costly medical trails involving thousands of patients.
All this procedure is very costly and inefficient and it is based on the assumption that human diseases can be cured with a single drug. However, it is quite obvious that the majority of us will not die because of a single faulty gene, but because of the combination of many small alterations on different genes (multifactorial diseases) combined with our life style. Multifactorial diseases are hard to treat since they involve more than one gene product in an organism, often working in different cellular pathways. Thus we need first to be able to understand in a global and quantitative way how a complex biological system as the human being operates, to be able to tackle in a rational way the treatment of complex diseases. This is precisely one of the aims of Systems Biology.
Gloria Lligadas | alfa
Two Group A Streptococcus genes linked to 'flesh-eating' bacterial infections
25.09.2017 | University of Maryland
Rainbow colors reveal cell history: Uncovering β-cell heterogeneity
22.09.2017 | DFG-Forschungszentrum für Regenerative Therapien TU Dresden
At the productronica trade fair in Munich this November, the Fraunhofer Institute for Laser Technology ILT will be presenting Laser-Based Tape-Automated Bonding, LaserTAB for short. The experts from Aachen will be demonstrating how new battery cells and power electronics can be micro-welded more efficiently and precisely than ever before thanks to new optics and robot support.
Fraunhofer ILT from Aachen relies on a clever combination of robotics and a laser scanner with new optics as well as process monitoring, which it has developed...
Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.
A warming planet
Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.
The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...
Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...
Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...
19.09.2017 | Event News
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25.09.2017 | Power and Electrical Engineering
25.09.2017 | Health and Medicine
25.09.2017 | Physics and Astronomy