Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New primate stem cell

01.02.2002


All the replacement tissues with none of the ethical dilemmas?
© Science


Dividing, unfertilised eggs could offer new therapeutic option

US researchers have cloned stem cells from the unfertilized eggs of primates - our closest animal relatives. The achievement suggests it may be possible to grow cells that can give rise to any tissue in the human body without cloning and destroying human embryos.

Some researchers in the field doubt whether the technique will work in humans. And opponents of therapeutic cloning do not believe the new cells solve any of the ethical dilemmas of producing embryonic stem (ES) cells.



Michael West at Advanced Cell Technology (ACT) in Worcester, Massachusetts, and colleagues tricked macaque egg cells into dividing without having first been fertilized. They used a chemical cocktail similar to the one sperm use to make eggs divide.

The dodge - called parthenogenesis - is done routinely with laboratory mice but ACT is the first to pull it off in primates. The resulting cells, called parthenotes, are clones of their mother. Experiments in mice suggest that parthenote embryos die before developing normally.

Stem-cell researchers’ ultimate goal is to replace any malfunctioning body tissue, such as diabetics faulty pancreas cells or the degrading nerve sheaths in multiple sclerosis patients. One of their greatest challenges is to get stem cells to commit to becoming a particular cell type - a process called differentiation.

Primate parthenotes are, if anything, easier to grow into different tissue types than ES cells, says West: "It’s all there: skin with hair follicles, developing eye tissue." His team even managed to create nerve cells that could produce dopamine. Human equivalents could replace the brain cells destroyed by Parkinson’s disease.

Limited application

"It’s an interesting step," says Harry Griffin, of the Roslin Institute in Scotland, birthplace of Dolly the cloned sheep. But he doubts whether parthenotes will provide an alternative to therapeutic cloning - itself a long way from becoming a medical reality.

Azim Surani, a developmental biologist at Cambridge University in England agrees: Parthenote cells lack the influence of male chromosomes, which have subtle effects on cell growth and development. Although West’s cells grow in the test tube, "we cannot assume that they will behave normally when implanted in an organism," he says.

Plus stem cell therapy aims to produce cells from the patient’s own tissue that exactly match their bodies cells. And the majority of diseases that stem cells would treat are age-related. Older women no longer produce egg cells from which to make parthenote stem cells, says Griffin.

West admits that parthenotes’ potential is not fully understood. But he feels that their ready availability could be a boon to stem-cell science. "Medical researchers need to have options," he says.

Still controversial

Unfortunately parthenotes don’t side-step all objections to creating human embryos as a source of stem cells. "The ethical issue is not solved by this," says Bill Saunders, spokesman for the Washington DC-based Family Research Council, which opposes the use of embryos in research.

Parthenotes, although unfertilized, do form embryos, so they are living, Saunders argues. "Single-celled organisms that have the capacity to divide and grow are a member of the human species," he says.

References

  1. Cibelli, J. B. et al. Parthenogenetic Stem Cells in Nonhuman Primates. Science, 295, 465(2002).


TOM CLARKE | © Nature News Service

More articles from Life Sciences:

nachricht Bolstering fat cells offers potential new leukemia treatment
17.10.2017 | McMaster University

nachricht Ocean atmosphere rife with microbes
17.10.2017 | King Abdullah University of Science & Technology (KAUST)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Ocean atmosphere rife with microbes

17.10.2017 | Life Sciences

Neutrons observe vitamin B6-dependent enzyme activity useful for drug development

17.10.2017 | Life Sciences

NASA finds newly formed tropical storm lan over open waters

17.10.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>