The NICB has received over €34.4 research funding from the HEA under the PRTLI Cycle 3 scheme, and has also received funding from SFI, Atlantic Philanthropies, Enterprise Ireland and the Health Research Board. The NICB occupies a unique niche in Ireland's R&D sector in the Irish third-level biomedical sector, applying molecular cell biology research to solving biomedical problems.
The centre, under the Directorship of Professor Martin Clynes, collaborates with a number of Dublin hospitals in the diagnosis and treatment of cancer, diabetes, eye disease and microbial diseases.
The NICB's first cancer drug treatment discovery has been taken into clinical trial with Professor John Crown in St Vincent's Hospital, Dublin. A team of researchers involved in research into resistance to chemotherapy drugs have identified a common arthritis drug, Sulindac, which can inhibit an important cancer resistance factor. Having successfuly completed Phase I of its clinical evaluation, Phase II is currently underway, examining the role of Sulindac in the improvement of the treatment of malignant melanoma. The trial represents the close partnership of scientists in the NICB, clinical researchers and clinicians, the All-Ireland Cooperative Oncology Group and the pharmaceutical industry.
"Although still in the early stages, this unique partnership is a model for the evolution of rational cancer treatment to improve treatments for Irish cancer patients", said Professor Martin Clynes.
Another research project includes the identification of molecular markers which are present in the blood which are indicative of the presence of a cancer and how the cancer is progressing. This new approach, if translated to the clinic, would mean that a standard blood test would allow the clinician to make early diagnosis of cancer even before the onset of systems. Cancers being investigated include breast, lung, pancreatic, renal and skin cancers.
The treatment of corneal blindness is the subject of another research project carried out by the NICB, the Royal Victoria Eye and Ear Hospital, the Irish Blood Transfusion Service and the Blond McIndoe Centre, in the UK. They are examining the molecular markers of corneal stem cells which can be 'grown' in the lab and used to treat a number of corneal diseases and injuries.
The NICB is also involved in a revolutionary new treatment for diabetes which will involve the harvesting of 'islets' from donors and transplanting them directly into the veins patients. These islets then produce insulin normally, bringing about an effective cure to the patients.
As a result of its expertise in mammalian cell culture technology, NICB is also involved in close collaboration with industry, including an SFI-funded €4m collaborative project with Wyeth Biopharma.
Shane Kenny | alfa
What happens in the cell nucleus after fertilization
06.12.2016 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
Researchers uncover protein-based “cancer signature”
05.12.2016 | Universität Basel
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
06.12.2016 | Materials Sciences
06.12.2016 | Medical Engineering
06.12.2016 | Power and Electrical Engineering