Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers discover mechanism that determines when detailed memories are retained

17.10.2006
The levels of a chemical released by the brain determine how detailed a memory will later be, according to researchers at UC Irvine.

The neurotransmitter acetylcholine, a brain chemical already established as being crucial for learning and memory, appears to be the key to adding details to a memory. In a study with rats, Norman Weinberger, research professor of neurobiology and behavior, and colleagues determined that a higher level of acetylcholine during a learning task correlated with more details of the experience being remembered. The results are the first to tie levels of acetylcholine to memory specificity and could have implications in the study and treatment of memory-related disorders.

The findings appear in the November issue of the journal Neurobiology of Learning and Memory.

"This is the first time that direct stimulation of a brain region has controlled the amount of detail in a memory," said Weinberger, a fellow at UCI's Center for the Neurobiology of Learning and Memory. "While it is likely that the brain uses a number of mechanisms to store specific details, our work shows that the level of acetylcholine appears to be a key part of that process."

... more about:
»Stimulation »acetylcholine »frequencies

In their experiments, the researchers exposed rats to tones of various frequencies. During some of the trials, they paired one tone with stimulation of a section of the rats' brains known as the nucleus basalis, which relays commands to the auditory cortex by secreting acetylcholine. During some experiments, the stimulation of the nucleus basalis was weak, whereas in other animals the stimulation was stronger. When the tones were replayed the next day, the scientists could measure how well they remembered the various frequencies by measuring changes in their respiration rates.

The results showed that a weak activation of the nucleus basalis, which resulted in a small amount of acetylcholine being released, did lead the rats to remember the tones but not specific frequencies. However, when the stimulation was greater (leading to the higher level of acetylcholine release), the rats also remembered the specific frequencies.

"We have always known that acetylcholine plays a major role in learning and memory," Weinberger said. "For example, the major treatments currently available for Alzheimer's disease work by making more acetylcholine available in the brain. Finding ways to control the levels of this key transmitter would be crucial for treating a number of memory-related disorders."

Weinberger is a pioneer in research in the field of learning and memory in the auditory system. In a study published in 2005, he discovered a neural coding mechanism that the brain relies upon to register the intensity of memories based on the importance of the experience. The study presented the first evidence that a "memory code" of any kind may exist. His laboratory also was the first to induce a specific memory by stimulating the system involving acetylcholine in the brain, setting the stage for the latest findings.

Farnaz Khadem | EurekAlert!
Further information:
http://www.uci.edu

Further reports about: Stimulation acetylcholine frequencies

More articles from Life Sciences:

nachricht Hunting pathogens at full force
22.03.2017 | Helmholtz-Zentrum für Infektionsforschung

nachricht A 155 carat diamond with 92 mm diameter
22.03.2017 | Universität Augsburg

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Pulverizing electronic waste is green, clean -- and cold

22.03.2017 | Materials Sciences

Astronomers hazard a ride in a 'drifting carousel' to understand pulsating stars

22.03.2017 | Physics and Astronomy

New gel-like coating beefs up the performance of lithium-sulfur batteries

22.03.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>