Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New research to cut animal testing

13.10.2006
Researchers at The University of Manchester have been awarded £130,000 to develop new techniques to reduce the need for animals in drug testing.

Current checks to establish whether a new drug is carcinogenic can be inconclusive and require further testing on live animals to establish whether they are harmful or not.

Dr Richard Walmsley and colleagues at the University spin-out company he founded, Gentronix, have developed techniques using cultured human cells to more effectively weed out cancer-causing compounds.

“The current pre-animal tests that are used are highly sensitive and so most carcinogens are identified,” said Dr Walmsley, who is based in the Faculty of Life Sciences.

... more about:
»Animal »Testing »compounds

“Unfortunately, such tests have poor specificity and a lot of safe compounds are also wrongly identified as potential carcinogens. This means that animal testing is still carried out, in case such compounds turn out to be safe.

“The testing process developed at Gentronix has proven very reliable at telling us whether a drug will cause cancer but some chemicals, called promutagens, only become carcinogenic once they have passed through the body’s liver.

“This grant will help us develop new non-animal experiments to identify these other toxic compounds and so reduce the need for animal testing.”

The funding – awarded by the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) – will help the scientists establish new genotoxicity tests using cultured human liver cells.

It is hoped the new test will not only reduce the number of compounds that are tested on animals but also ensure harmless chemicals that could prove to be useful new drugs are not falsely labelled as carcinogens.

“I don’t believe that animal testing will disappear from drug safety assessment in the short term as you can’t ask human volunteers to take novel drugs straight from testing done in tube tests,” said Dr Walmsley.

“But if we can refine the pre-animal tests and increase people’s confidence in them, then we will be able to reduce the number of chemicals that are tested on live animals.”

Aeron Haworth | alfa
Further information:
http://www.manchester.ac.uk
http://www.gentronix.co.uk
http://www.nc3rs.org.uk

Further reports about: Animal Testing compounds

More articles from Life Sciences:

nachricht New printing technique uses cells and molecules to recreate biological structures
20.02.2018 | Queen Mary University of London

nachricht In living color: Brightly-colored bacteria could be used to 'grow' paints and coatings
20.02.2018 | University of Cambridge

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

Im Focus: Interference as a new method for cooling quantum devices

Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters

Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Major discovery in controlling quantum states of single atoms

20.02.2018 | Physics and Astronomy

New printing technique uses cells and molecules to recreate biological structures

20.02.2018 | Life Sciences

New tech for commercial Lithium-ion batteries finds they can be charged 5 times fast

20.02.2018 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>