Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Scientists identify protein with a crucial role in cell death

14.07.2006
Ageing, and the processes of deterioration that go with it, are largely attributable to cells that die off in a controlled manner.

Therefore, gaining better understanding of this controlled cell death is very important in the fight against deterioration diseases like dementia. In this light, researchers from the Flanders Interuniversity Institute for Biotechnology (VIB) connected to the K.U.Leuven, in collaboration with researchers from the Dulbecco-Telethon Institute hosted by the Veneto Institute of Molecular Medicine in Padua (Italy), have now discovered the function of the PARL protein. By studying mice that are unable to produce PARL, the researchers have discovered the significance of this protein in controlled cell death. An important step toward a good understanding of the ageing processes and of diseases like Parkinson’s disease.

The cells’ energy suppliers

Every living thing is composed of cells. There are a number of different cell types (brain cells, for example), each with its own particular function. To be able to perform their work, cells need energy. And this is what the mitochondria - which convert oxygen into the necessary energy - are responsible for. Given this vital function, scientists have suspected that the inner workings of a cell depend largely on how the mitochondria function. Therefore, it has been suspected that poorly functioning mitochondria can, among other things, lead to a disturbance in brain cells and thus contribute to Parkinson’s disease.

A noble stranger...

This starting assumption brought two top researchers together: Bart De Strooper, who has extensive experience in Alzheimer research and is thus also interested in the causes of Parkinson’s disease, and Luca Scorrano, who specializes in the functioning and effect of mitochondria. They set out to study PARL, a protein thought to interact with Presenilin, one of the major players in Alzheimer’s disease. Previous research had already indicated that the link between PARL and Presenilin is negligible. It was understood that PARL is important to the cell’s mitochondria, but the protein’s particular function has remained unknown for a long time.

‘Knock-out’ mice

To obtain insight into PARL’s function, the researchers used mice - called ‘knock-out’ mice - that were no longer able to produce this protein. These mice deteriorated very rapidly - losing muscular strength after only 4 weeks, which greatly reduced their capacity for breathing - and, after 8 to 12 weeks, they died. Thus, a lack of PARL leads to weakening of (muscle) cells, a phenomenon that also occurs in the normal ageing process. This result spurred the researchers on to find out the function of PARL.

Controlled cell death

During our lifetime, cells die off in a controlled manner - a process called apoptosis. In addition to supplying energy, mitochondria also ensure the integration and amplification of apoptosis signaling in the cell. From the research of De Strooper and Scorrano, it turns out that PARL is a key to initiating apoptosis in the mitochondria. Although the mitochondria of the knock-out mice have a normal development and are able to convert oxygen into energy, they have apparently lost their protection against apoptosis, and so the cells die off more quickly. Therefore, PARL plays a crucial role in the cells’ dying off process and, consequently, probably also in the origin of diseases of ageing, like Parkinson’s disease.

Ann Van Gysel | alfa
Further information:
http://www.vib.be

More articles from Life Sciences:

nachricht New risk factors for anxiety disorders
24.02.2017 | Julius-Maximilians-Universität Würzburg

nachricht Stingless bees have their nests protected by soldiers
24.02.2017 | Johannes Gutenberg-Universität Mainz

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>