One long-standing observation concerning the physiological decline that accompanies aging is its variability--some people age better than others. However, there has thus far been little or no evidence supporting the existence of similar heterogeneity at the level of gene expression. Lack of such evidence, in turn, gives support to a "programmed aging" hypothesis and argues against the more commonly accepted "stochastic aging" model, in which random biological events play an important role.
In the new work, researchers put to the test the question of whether gene-expression heterogeneity increases with age. Using a wide range of expression data from both humans and rats, the researchers showed that levels of gene expression become more variable with age. Furthermore, they found that the tendency toward increased variation is not restricted to a specific set of genes, implying that increased heterogeneity is the outcome of random processes such as genetic mutation.
These observations corroborate the notion that aging is underpinned by stochastic events. That said, the authors of the study point out that the observed increases in expression variation are surprisingly small, leaving plenty of room for further explanations regarding the relationship between aging-related changes at the organismal level and the underlying molecular mechanisms of aging. Nevertheless, the new results show that with the increasing amounts of molecular data available to researchers, scientists will now experience improved opportunities to answer age-old questions about the nature of aging.
Heidi Hardman | EurekAlert!
Cryo-electron microscopy achieves unprecedented resolution using new computational methods
24.03.2017 | DOE/Lawrence Berkeley National Laboratory
How cheetahs stay fit and healthy
24.03.2017 | Forschungsverbund Berlin e.V.
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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24.03.2017 | Physics and Astronomy