Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Discovery points to more effective ways of regulating cell signalling

24.04.2006
A discovery made at The Walter and Eliza Hall Institute provides new insights into enhancing the function of the protein SOCS3, which regulates the response of cells to external stimuli.

SOCS3 (Suppressors of Cytokine Signalling) controls the responses of cells to cytokines (growth factors). It is important that cytokine signalling is properly regulated within the human body. If SOCS3 permits cytokine signalling to be too "loud", then the excess of growth signals can cause crippling inflammatory diseases such as Rheumatoid Arthritis or diseases where cells multiply uncontrollably – cancer.

Conversely, if cytokine signalling is overly repressed by SOCS3, then bone marrow is deprived of sufficient white blood cells required to rejuvenate the damaged immune system following chemotherapy. An unfortunate side effect of chemotherapy is damage caused to the bone marrow that produces the white blood cells of the immune system. This leaves cancer patients prey to opportunistic infections that can delay and adversely affect their recovery.

A cytokine called G-CSF (developed in previous years at WEHI) is in clinical use worldwide to stimulate the restoration of bone marrow and the reinvigoration of the immune system in chemotherapy patients. The success of G-CSF (or Granulocyte Colony Stimulating Factor) depends on the complementary proper functioning of SOCS3.

A research team at WEHI has determined the three-dimensional structure of SOCS3. This discovery about the structure may enable the design of selective inhibitors of SOCS3 that might be useful in extending the activity of G-CSF in restoring white blood cells.

The structure also showed that SOCS3 contains a region that could be engineered out, improving the stability of SOCS3. This newly engineered version of SOCS3 also has the potential to enhance its repressive functions, which may allow inflammatory diseases to be treated more effectively.

Brad Allen | EurekAlert!
Further information:
http://www.researchaustralia.com.au/

More articles from Life Sciences:

nachricht Water forms 'spine of hydration' around DNA, group finds
26.05.2017 | Cornell University

nachricht How herpesviruses win the footrace against the immune system
26.05.2017 | Helmholtz-Zentrum für Infektionsforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>