Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Discovery points to more effective ways of regulating cell signalling

24.04.2006
A discovery made at The Walter and Eliza Hall Institute provides new insights into enhancing the function of the protein SOCS3, which regulates the response of cells to external stimuli.

SOCS3 (Suppressors of Cytokine Signalling) controls the responses of cells to cytokines (growth factors). It is important that cytokine signalling is properly regulated within the human body. If SOCS3 permits cytokine signalling to be too "loud", then the excess of growth signals can cause crippling inflammatory diseases such as Rheumatoid Arthritis or diseases where cells multiply uncontrollably – cancer.

Conversely, if cytokine signalling is overly repressed by SOCS3, then bone marrow is deprived of sufficient white blood cells required to rejuvenate the damaged immune system following chemotherapy. An unfortunate side effect of chemotherapy is damage caused to the bone marrow that produces the white blood cells of the immune system. This leaves cancer patients prey to opportunistic infections that can delay and adversely affect their recovery.

A cytokine called G-CSF (developed in previous years at WEHI) is in clinical use worldwide to stimulate the restoration of bone marrow and the reinvigoration of the immune system in chemotherapy patients. The success of G-CSF (or Granulocyte Colony Stimulating Factor) depends on the complementary proper functioning of SOCS3.

A research team at WEHI has determined the three-dimensional structure of SOCS3. This discovery about the structure may enable the design of selective inhibitors of SOCS3 that might be useful in extending the activity of G-CSF in restoring white blood cells.

The structure also showed that SOCS3 contains a region that could be engineered out, improving the stability of SOCS3. This newly engineered version of SOCS3 also has the potential to enhance its repressive functions, which may allow inflammatory diseases to be treated more effectively.

Brad Allen | EurekAlert!
Further information:
http://www.researchaustralia.com.au/

More articles from Life Sciences:

nachricht Flow of cerebrospinal fluid regulates neural stem cell division
22.05.2018 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

nachricht Chemists at FAU successfully demonstrate imine hydrogenation with inexpensive main group metal
22.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

Im Focus: Computer-Designed Customized Regenerative Heart Valves

Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.

Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...

Im Focus: Light-induced superconductivity under high pressure

A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.

Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Supersonic waves may help electronics beat the heat

18.05.2018 | Power and Electrical Engineering

Keeping a Close Eye on Ice Loss

18.05.2018 | Information Technology

CrowdWater: An App for Flood Research

18.05.2018 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>