Ever since the advent of recombinant-DNA technology, scientists have conceived that it will be feasible to create entirely new enzymes for specific needs. In an article in todays issue of the journal Science, researchers from Uppsala and Korea present concrete proof of this. They have succeeded in converting an enzyme involved in normal human metabolism into an enzyme that is custom-designed to break down a specific substance, cefotaxime.
“The product in this case is not the main point, but we have shown that it is possible to totally transform an enzyme for a new and pre-determined activity. We have succeeded by using a rational reconstruction of the enzymes active site in combination with directed molecular evolution in test tubes,” says Professor Bengt Mannervik, at the Department of Biochemistry and Organic Chemistry, who planned the study.
In the cells of all organisms, proteins are involved in molecular functions of highly disparate types: as receptors of light and smells, for transmission of signals, mechanical work, control of the function of genes, and the synthesis and degradation of chemical substances. Despite all of these diverse functions, only an insignificant number of all imaginable protein structures ever come to existence in living cells. With the help of recombinant-DNA technology and chemical modifications scientists around the world are therefore trying to produce entirely new proteins that can be used for biotechnological applications in medicine, the drug industry, forestry and agriculture, and the production of foodstuffs. However, researchers have had to look for proteins at random after reconstructions, like a needle in a haystack.
North and South Cooperation to Combat Tuberculosis
22.03.2018 | Universität Zürich
Researchers Discover New Anti-Cancer Protein
22.03.2018 | Universität Basel
An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.
The incidence of liver cancer, also known as hepatocellular carcinoma, is steadily increasing. In the last twenty years, the number of cases has almost doubled...
In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.
Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...
Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.
They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...
A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...
For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.
In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...
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22.03.2018 | Earth Sciences
22.03.2018 | Earth Sciences