A new paper in the January 15th issue of G&D provides the structural basis by which FGF8 splice isoforms (FGF8a and FGF8b) differ in their ability to pattern embryonic brain. FGF8b differs from FGF8a solely by the presence of 11 additional amino acids at its N-terminus.
However, only FGF8b can transform midbrain to cerebellum whereas FGF8a causes an overgrowth of midbrain. Dr. Moosa Mohammadis research team has solved the crystal structure of FGF8b in complex with the FGFR2c receptor, and shows that additional contacts between a single amino acid from the alternatively spliced region of FGF8b with the FGFR2c receptor account for the unique ability of FGF8b to transform midbrain to hindbrain during embryogenesis.
The structural and biochemical data not only provide novel insights into the molecular mechanisms of brain development, but also serves as a framework for examining the role of individual FGF8 isoforms in patterning and development of limb, eye, ear and lung. Moreover, this study is the first to demonstrate that differences in the strength of interaction of closely related growth factors with a common receptor can serve as a regulatory mechanism in cellular signaling.
Heather Cosel | EurekAlert!
Toward a 'smart' patch that automatically delivers insulin when needed
18.01.2017 | American Chemical Society
127 at one blow...
18.01.2017 | Stiftung Zoologisches Forschungsmuseum Alexander Koenig, Leibniz-Institut für Biodiversität der Tiere
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).
Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...
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