Drs. Elisavet Maniataki and Zissimos Mourelatos (UPENN School of Medicine) report on the pathway of human RISC assembly from pre-microRNAs (miRNAs), highlighting important differences from the siRNA-fueled RISC assembly pathway in Drosophila.
The authors identified a protein complex between Dicer and Argo2 – the "microRNA loading complex" (miRLC) – that lacks miRNAs. Without a requirement for ATP, miRLC catalyzes RISC assembly and disassembly to release the miRNP.
"This study demonstrates that, in humans, pre-miRNA processing is coupled with RISC/miRNP assembly and involves a preformed protein complex that catalyzes all steps that constitute the cytoplasmic phase of RNAi," explains Dr. Mourelatos.
Heather Cosel | EurekAlert!
New risk factors for anxiety disorders
24.02.2017 | Julius-Maximilians-Universität Würzburg
Stingless bees have their nests protected by soldiers
24.02.2017 | Johannes Gutenberg-Universität Mainz
In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".
Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...
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