Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Flu jab – convenient, safe and long-term

09.12.2005


Strictly speaking, the ‘choked’, i.e., inactivated three viruses (A1, A2, B) in the new vaccine will be the same as before. They are included in the vaccine composition on the recommendation of the World Health Organisation. But the additional substances, however, proposed by the researchers, are what make it possible to make this vaccine in tablet form. What is more, believe the authors, this vaccine will be more efficient than all known equivalents. Not because an injection is replaced with a tablet, but because the authors propose to include a so-called adjuvant into the vaccine composition; put simply – an enhancer for the effect of the vaccine. The scientists are already confident of its effectiveness: A similar, intranasal vaccine which they developed previously (what specialists call nasal drops) with the same adjuvant is already at clinical trial stage. The first volunteers will be testing it in the first clinical trials this autumn.



So, the most important component of this vaccine is Korauban, an original immunostimulant, or a substance that intensifies immunity. Its correct name is a stimulant of immunogenesis, a gamma-interferon inductor. This is a close relative of regular cellulose; the same polysaccharide, only of a slightly different structure. It is produced by ‘specially trained’ microorganisms and it serves to enhance the action of the vaccine.

Korauban, if we are to greatly simplify the matter, calls special cells, which are to eliminate alien elements, to where the decontaminated virus has struck, and it presents the enemy to them. As a result the organism strenuously produces protection – special proteins (antibodies) and cells, both directed to the form of the enemy. What is of especial importance is that, as a result, humans produce so-called local cell immunity, of a long-term and wide-ranging action; not only against the used vaccine and existing epidemic viruses, but also against the pathogens of future epidemics. And in the region of the nose and throat. It is with damage to the latter, incidentally, that the illness begins. In the first days flu usually passes without a cold.


‘The combination of Korauban and vaccine viruses in one preparation leads to a synergy of their action,’ states Project manager Oleg Kuznetsov. ‘This is displayed in an increase in early synthesis of common interferon, a factor of the synthesis of intensified non-specific resistance of the organism to bacterial and viral infections. Obviously the preparation could be applied for emergency protection not only from flu but also from other acute respiratory viral infections. Such a protection would suffice for a week; further, a specific protection against flu will begin to act’.

Finally, there is another substance in the composition of the tablet, which ensures the tablet-vaccine remains stable for a 12-month period. The scientists will obtain the first clinical test results no earlier than next Spring. For now it will be in the form of drops in aerosol form and not tablets. However, the authors are confident of its success. The vaccine demonstrated high efficiency on laboratory animals and proved to be completely non-toxic. The researchers believe that this ‘jab’ will need to be taken once every few years. The sooner the better.

Andrew Vakhliaev | alfa
Further information:
http://tech-db.istc.ru/istc/sc.nsf/html/hi-tech.htm

More articles from Life Sciences:

nachricht For a chimpanzee, one good turn deserves another
27.06.2017 | Max-Planck-Institut für Mathematik in den Naturwissenschaften (MPIMIS)

nachricht New method to rapidly map the 'social networks' of proteins
27.06.2017 | Salk Institute

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Touch Displays WAY-AX and WAY-DX by WayCon

27.06.2017 | Power and Electrical Engineering

Drones that drive

27.06.2017 | Information Technology

Ultra-compact phase modulators based on graphene plasmons

27.06.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>