Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Flu jab – convenient, safe and long-term

09.12.2005


Strictly speaking, the ‘choked’, i.e., inactivated three viruses (A1, A2, B) in the new vaccine will be the same as before. They are included in the vaccine composition on the recommendation of the World Health Organisation. But the additional substances, however, proposed by the researchers, are what make it possible to make this vaccine in tablet form. What is more, believe the authors, this vaccine will be more efficient than all known equivalents. Not because an injection is replaced with a tablet, but because the authors propose to include a so-called adjuvant into the vaccine composition; put simply – an enhancer for the effect of the vaccine. The scientists are already confident of its effectiveness: A similar, intranasal vaccine which they developed previously (what specialists call nasal drops) with the same adjuvant is already at clinical trial stage. The first volunteers will be testing it in the first clinical trials this autumn.



So, the most important component of this vaccine is Korauban, an original immunostimulant, or a substance that intensifies immunity. Its correct name is a stimulant of immunogenesis, a gamma-interferon inductor. This is a close relative of regular cellulose; the same polysaccharide, only of a slightly different structure. It is produced by ‘specially trained’ microorganisms and it serves to enhance the action of the vaccine.

Korauban, if we are to greatly simplify the matter, calls special cells, which are to eliminate alien elements, to where the decontaminated virus has struck, and it presents the enemy to them. As a result the organism strenuously produces protection – special proteins (antibodies) and cells, both directed to the form of the enemy. What is of especial importance is that, as a result, humans produce so-called local cell immunity, of a long-term and wide-ranging action; not only against the used vaccine and existing epidemic viruses, but also against the pathogens of future epidemics. And in the region of the nose and throat. It is with damage to the latter, incidentally, that the illness begins. In the first days flu usually passes without a cold.


‘The combination of Korauban and vaccine viruses in one preparation leads to a synergy of their action,’ states Project manager Oleg Kuznetsov. ‘This is displayed in an increase in early synthesis of common interferon, a factor of the synthesis of intensified non-specific resistance of the organism to bacterial and viral infections. Obviously the preparation could be applied for emergency protection not only from flu but also from other acute respiratory viral infections. Such a protection would suffice for a week; further, a specific protection against flu will begin to act’.

Finally, there is another substance in the composition of the tablet, which ensures the tablet-vaccine remains stable for a 12-month period. The scientists will obtain the first clinical test results no earlier than next Spring. For now it will be in the form of drops in aerosol form and not tablets. However, the authors are confident of its success. The vaccine demonstrated high efficiency on laboratory animals and proved to be completely non-toxic. The researchers believe that this ‘jab’ will need to be taken once every few years. The sooner the better.

Andrew Vakhliaev | alfa
Further information:
http://tech-db.istc.ru/istc/sc.nsf/html/hi-tech.htm

More articles from Life Sciences:

nachricht Embryonic development: How do limbs develop from cells?
18.05.2018 | Humboldt-Universität zu Berlin

nachricht Reading histone modifications, an oncoprotein is modified in return
18.05.2018 | American Society for Biochemistry and Molecular Biology

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

Im Focus: Computer-Designed Customized Regenerative Heart Valves

Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.

Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...

Im Focus: Light-induced superconductivity under high pressure

A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.

Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Supersonic waves may help electronics beat the heat

18.05.2018 | Power and Electrical Engineering

Keeping a Close Eye on Ice Loss

18.05.2018 | Information Technology

CrowdWater: An App for Flood Research

18.05.2018 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>