A protein that plays an important regulatory role in heart failure in the heart also exerts powerful effects on the adrenal gland, Jefferson Medical College researchers have found. The protein, GRK2, is a potential drug target for heart failure.
Walter Koch, Ph.D., director of the Center for Translational Medicine in the Department of Medicine at Jefferson Medical College of Thomas Jefferson University in Philadelphia, and his co-workers had showed previously that GRK2, or G-protein coupled receptor kinase 2, is increased in the heart in heart failure, and shuts off certain receptors called beta-adrenergic receptors, desensitizing them.
When the heart is failing, the body’s sympathetic nervous system, which kicks into gear in the so-called fight or flight response, goes to work, releasing catecholamines – hormones such as epinephrine and norepinephrine in an ill-conceived attempt to stimulate the heart.
Steve Benowitz | EurekAlert!
22.02.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau
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