Institut Curie and Inserm research scientists and physicians have just shown that precise knowledge of alterations in chromosome 1 can be used to improve the treatment of gliomas, the most frequent brain tumors in adults. Diagnosis and treatment of these tumors are difficult because of their heterogeneity and variable malignancy. Using DNA chips, the authors of this report were able to distinguish the tumors with the best prognosis, whose chromosome 1 has undergone a specific deletion. Screening for these deletions should be incorporated into standard diagnostic tests by the end of 2005.
When CGH chips light up… Each point represents a DNA probe of about 150 000 base pairs on which the sample DNA has hybridized. The green spots correspond to regions where a deletion has occurred, and the red spots to regions that have been amplified. © Ahmed Idbaih/Institut Curie
These results are published in the September 2005 issue of Annals of Neurology.
Gliomas are the most frequent brain tumors in adults, and account for over 50% of primary tumors. They are classified into three groups: astrocytomas – 70% of all these tumors – derive from astrocytes, cells close to the neurones; oligodendrogliomas derive from cells that produce the sheaths of nerve fibers; and oligoastrocytomas which are mixed tumors combining the characteristics of the first two types.
Catherine Goupillon | alfa
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Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
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Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
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In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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