Tumor cells can grow without control by weakening specific cells of the immune system, the T-cells, which normally detect and destroy tumor cells. The findings of Dr. Gerald Willimsky and Prof. Thomas Blankenstein (Max Delbrück Center for Molecular Medicine, MDC, Berlin-Buch and Charité) were generated in transgenic mice over a period of seven years and have now been published in the scientific journal Nature* (doi:10.1038/nature03954). Until now, the notion was that tumor cells escape recognition and subsequent destruction by T-cells by hiding.
Furthermore, Dr. Willimsky and Prof. Blankenstein could show that the immune system recognizes tumors derived from single cells and strongly reacts, for example by the increase in T-cells. However, these T-cells do not function. The findings of the two immunologists refer to sporadic tumors which develop without influence from the outside. T-cells on the other hand can control cancers caused by viral infection (e.g., B cell lymphomas triggered by Epstein Barr viruses). Even though tumor cells weaken the immune system, the two researchers are convinced that there is still hope for an immune therapy because tumor cells do not lose their structures which are targets for immune cells, making them still vulnerable for detection and destruction.
Barbara Bachtler | alfa
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23.08.2017 | American Chemical Society
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23.08.2017 | Empa - Eidgenössische Materialprüfungs- und Forschungsanstalt
Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
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23.08.2017 | Life Sciences
23.08.2017 | Life Sciences
23.08.2017 | Physics and Astronomy