Research published in Nature (21 July) will outline for the first time the stem cell origin of the structure of the neck and shoulders in vertebrates. The scientists believe that instead of groups of stem cells creating the skeletal and muscle structure separately they actually appear to make them together as a sort of ‘composite’. This could have significant implications for clinical medicine and our understanding of vertebrate evolution.
Scientists at the Wolfson Institute for Biomedical Research of University College London, part-funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and working with international collaborators, used a new genetic technique to tag embryonic stem cells and then trace them to the adult animal. They discovered that instead of homogeneous groups of stem cells making up the bones of the shoulder and neck and another making the muscles, a newly-discovered group of stem cells called mesenchymal stem cells make both the muscles and the point where it joins the skeleton.
The researchers believe their results show that the skeleton and muscles of vertebrates should not be seen as separate but instead are composites, with the boundaries between cell groups blurred around the body. For example, the stem cell group that makes the connective tissues of the swallowing/gulping muscles also makes the skeletal regions of the shoulder girdle. This sheds new light on human diseases such as Klippel-Feil syndrome where both regions are often malformed.
Matt Goode | alfa
Rainbow colors reveal cell history: Uncovering β-cell heterogeneity
22.09.2017 | DFG-Forschungszentrum für Regenerative Therapien TU Dresden
The pyrenoid is a carbon-fixing liquid droplet
22.09.2017 | Max-Planck-Institut für Biochemie
Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.
A warming planet
Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.
The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...
Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...
Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...
For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.
Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...
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22.09.2017 | Medical Engineering
22.09.2017 | Physics and Astronomy