Using technology that makes it possible to zoom in on smaller sections of cell chromosomes than ever before, researchers at Dana-Farber Cancer Institute have identified nearly 100 chromosome regions where genes are either over-copied or missing in non-small cell lung cancer. The findings provide new clues about the location of genes potentially involved in the most common type of lung cancer –– and one of the deadliest of all malignancies –– and a range of possible targets for future therapies.
The study will be reported in the Proceedings of the National Academy of Sciences Online Early Edition the week of June 27.
"Previous studies have identified a small set of mutated, or abnormal, genes that are associated with non-small cell lung cancer," says the studys lead author, Giovanni Tonon, MD, PhD, of Dana-Farber. "But we also know that the chromosomes of these cells contain a large number of irregular regions –– where genes have either been deleted or copied over and over again –– which suggests that a large number of cancer genes remain to be discovered. The purpose of this study was to locate the likeliest candidates."
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