Credit: Dr. Mickie Bhatia
A study published in the May issue of Developmental Cell identifies specific genes that appear to be key players in the regulation of human-blood stem cells. This work is the first to validate gene expression analysis in human stem cells with functional experiments. The findings also suggest that changes in the expression of genes associated with universal cell signaling pathways can have a substantial impact on human stem cell behavior.
Formation and ongoing maintenance of blood cells begins with a rare cell called a hematopoietic stem cell (HSC) that has the ability to make more copies of itself or differentiate into progenitors that then form red blood cells, various types of white blood cells, or platelets. Blood cells must be constantly renewed throughout the lifetime of an animal, so control and regulation of HSCs is critical for survival. Although it is clear that the capacity for HSC proliferation and differentiation declines with age, not much is known about exactly how HSC physiology is regulated.
Dr. Mickie Bhatia and colleagues from the Robarts Research Institute in Ontario used genome-wide gene-expression profiling (microarray analysis) to examine purified subsets of defined blood-cell populations containing progenitors or HSCs from multiple stages of human development. The researchers identified two genes that act independently to enhance cell-cycle progression and inhibit cell death specifically in HSCs. The role of one gene, HES-1, ties in with previous research pointing to the importance of the cell-cycle-associated Notch signaling pathway. The second gene, HLF, is a DNA-binding transcription factor involved in preventing premature HSC death. Bhatia and colleagues showed that raising the amount of either gene in human HSCs increased their capacity for forming blood cells when they were transferred into mice.
Heidi Hardman | EurekAlert!
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Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.
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In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
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