Credit: Dr. Mickie Bhatia
A study published in the May issue of Developmental Cell identifies specific genes that appear to be key players in the regulation of human-blood stem cells. This work is the first to validate gene expression analysis in human stem cells with functional experiments. The findings also suggest that changes in the expression of genes associated with universal cell signaling pathways can have a substantial impact on human stem cell behavior.
Formation and ongoing maintenance of blood cells begins with a rare cell called a hematopoietic stem cell (HSC) that has the ability to make more copies of itself or differentiate into progenitors that then form red blood cells, various types of white blood cells, or platelets. Blood cells must be constantly renewed throughout the lifetime of an animal, so control and regulation of HSCs is critical for survival. Although it is clear that the capacity for HSC proliferation and differentiation declines with age, not much is known about exactly how HSC physiology is regulated.
Dr. Mickie Bhatia and colleagues from the Robarts Research Institute in Ontario used genome-wide gene-expression profiling (microarray analysis) to examine purified subsets of defined blood-cell populations containing progenitors or HSCs from multiple stages of human development. The researchers identified two genes that act independently to enhance cell-cycle progression and inhibit cell death specifically in HSCs. The role of one gene, HES-1, ties in with previous research pointing to the importance of the cell-cycle-associated Notch signaling pathway. The second gene, HLF, is a DNA-binding transcription factor involved in preventing premature HSC death. Bhatia and colleagues showed that raising the amount of either gene in human HSCs increased their capacity for forming blood cells when they were transferred into mice.
Heidi Hardman | EurekAlert!
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The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.
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