Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Molecule on immune cells linked to sexual transmission of HIV

25.04.2005


UCLA AIDS Institute discovery points to new drug target



Scientists have long suspected that HIV hijacks immune cells called dendritic cells to infiltrate the immune system. Now UCLA AIDS Institute researchers have shown that blocking HIV’s access to a naturally occurring molecule on dendritic cells may cut their ability to smuggle the virus into other immune cells. Published in the May edition of the Journal of Virology, the discovery may lead to new drugs to prevent sexually transmitted HIV infection.

"Dendritic cells act like sentries to alert the immune system when a foreign agent tries to infiltrate the body," said Dr. Benhur Lee, UCLA assistant professor of microbiology, immunology and molecular genetics. "They also produce a molecule called DC-SIGN that plays a critical role in the sexual transmission of HIV. We wanted to see what would happen if we blocked how DC-SIGN functions in its natural environment."


Dendritic cells reside in the mucosal linings of the mouth, gut, genital and urinary tracts -- sites where sexually transmitted HIV often enters the body. By examining biopsies of human rectal tissues, the UCLA team was the first to study DC-SIGN on dendritic cells in their natural setting instead of a test tube.

Using a sugar-like compound that binds to DC-SIGN and a DC-SIGN-seeking antibody, the scientists were able to block HIV from binding to these dendritic cells.

"Our findings suggest that preventing HIV from binding to the dendritic cells may block their ability to carry HIV to other parts of the immune system," Lee said. "Our next step will be to investigate if this is true."

"We believe our findings point to a new therapeutic target for preventing HIV infection," said Dr. Peter Anton, UCLA professor of medicine. "Drugs could be developed to block the interaction between HIV and DC-SIGN, potentially reducing HIV’s ability to spread infection at mucosal routes into the body."

Elaine Schmidt | EurekAlert!
Further information:
http://www.ucla.edu

More articles from Life Sciences:

nachricht Tag it EASI – a new method for accurate protein analysis
19.06.2018 | Max-Planck-Institut für Biochemie

nachricht How to track and trace a protein: Nanosensors monitor intracellular deliveries
19.06.2018 | Universität Basel

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

Im Focus: Photoexcited graphene puzzle solved

A boost for graphene-based light detectors

Light detection and control lies at the heart of many modern device applications, such as smartphone cameras. Using graphene as a light-sensitive material for...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Carbon nanotube optics provide optical-based quantum cryptography and quantum computing

19.06.2018 | Physics and Astronomy

How to track and trace a protein: Nanosensors monitor intracellular deliveries

19.06.2018 | Life Sciences

New material for splitting water

19.06.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>