Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New treatment for hereditary breast cancer

14.04.2005


Researchers at Stockholm University have, together with colleagues in England, discovered a new way of treating and preventing hereditary breast cancer. The article, published in Nature, describes how the use of a chemical inhibitor can specifically kill tumour cells, which have a defect in the gene causing hereditary breast cancer. This new treatment targets only the tumour cells and is not likely to affect other healthy cells in the body. The discovery could also lead to a prophylactic treatment for hereditary breast cancer.



In most women, the BRCA1 and BRCA2 genes prevent breast tumours from forming, but some women have inherited mutations in these genes, giving them about an eighty per cent risk of developing breast cancer.

Normal cells replicate by dividing DNA into two strands and copying each strand. Before replication, damage in the DNA is usually repaired using a protein called PARP. If PARP is absent or inhibited then the cells use a second mechanism called recombination to fix the damage and continue to replicate. Cells with mutated BRCA genes can’t undergo recombination and therefore rely completely on PARP to fix the damage.


The new treatment uses a chemical that prevents PARP from repairing the DNA, making recombination essential. The breast cancer tumour cannot perform recombination and is therefore unable to replicate and create new cells. The tumour is then unable to grow and eventually dies.

The beauty of this system is that only the tumour cells lack BRCA genes and thus only they completely rely on PARP. The other cells in the body are likely to be unaffected by the treatment and continue to use recombination to repair any mistakes that occur."

-- Since normal cells don’t need the PARP backup system to survive we could use PARP inhibitors as a prophylactic treatment to kill BRCA deficient cells before they grow out to tumours, says Dr Thomas Helleday, associate professor at Stockholm University who runs the research group. Both the treatment and the possible use as a preventive treatment are new concepts in cancer therapy. They could lead to revolutionary new treatments for women with hereditary breast cancer within the next five years or so.

Agneta Paulsson | EurekAlert!
Further information:
http://www.su.se

More articles from Life Sciences:

nachricht Cryo-electron microscopy achieves unprecedented resolution using new computational methods
24.03.2017 | DOE/Lawrence Berkeley National Laboratory

nachricht How cheetahs stay fit and healthy
24.03.2017 | Forschungsverbund Berlin e.V.

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>