A combination of four proteins that result from inflammation and infection and lead to premature birth can be rapidly and accurately detected in the amniotic fluid of pregnant women using proteomics technology, Yale researchers report in two studies in the February issue of British Journal of Obstetrics and Gynecology.
Using proteomics science, the Yale team, in collaboration with two other academic institutions, developed a novel method called MR scoring to discriminate healthy from diseased women in whom preterm delivery is impending and the health of the fetus is in danger. MR scoring relies on identification of a group of proteins that serve as biomarkers characteristic to women who will deliver preterm. The proteins detected are Human neutrophil defensin 1, Human neutrophil defensin 2, Calgranulin C and Calgranulin A.
"We are probably at a turning point in the history of preterm labor diagnosis," said Irina Buhimschi, M.D., research scientist in the Department of Obstetrics & Gynecology and Reproductive Sciences. "While many proteins are present in the amniotic fluid, not all are biomarkers with diagnostic significance."
Karen N. Peart | EurekAlert!
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