Scientists from MITs Center for Cancer Research have developed a new mouse model that closely resembles Li-Fraumeni Syndrome (LFS) in humans, a syndrome that predisposes those affected to a broad range of cancers. Some 95 percent of LFS patients develop cancer by age 65.
This work, which was reported in the Dec. 17 issue of Cell, could lead to a treatment for LFS and aid in the development of treatments for other cancers.
The research shows that a single point mutation in the tumor suppressor gene p53 yields a mouse that develops a broad tumor spectrum reminiscent of LFS. Although LFS is a rare genetic disease, affecting fewer than 400 families worldwide, the p53 gene is very commonly mutated in tumors unrelated to LFS. Mutations in p53 are detected in more than 50 percent of all human tumors, such as colon, breast, skin, bladder and many cancers of the digestive tract. Consequently, the development of a therapy for LFS specifically targeted at p53 has the potential to be applied to a wide range of cancers.
Elizabeth Thomson | MIT News Office
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Scientists have developed a new method of characterizing graphene’s properties without applying disruptive electrical contacts, allowing them to investigate both the resistance and quantum capacitance of graphene and other two-dimensional materials. Researchers from the Swiss Nanoscience Institute and the University of Basel’s Department of Physics reported their findings in the journal Physical Review Applied.
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The world's highest gain high power laser amplifier - by many orders of magnitude - has been developed in research led at the University of Strathclyde.
The researchers demonstrated the feasibility of using plasma to amplify short laser pulses of picojoule-level energy up to 100 millijoules, which is a 'gain'...
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
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Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
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An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
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