Researchers at The Molecular Sciences Institute revealed means for sensitive detection and precise quantification of arbitrarily designated molecules. The work is published in the current issue of Nature Methods.
The Cover Article, entitled "Using protein-DNA chimeras to detect and count small numbers of molecules," describes "tadpole" molecules, and their use to detect and count small numbers of proteins and other molecules.
Detection and quantification methods based on these molecules have exquisite sensitivity, immense dynamic range, and unprecedented quantitative precision. These attributes should make the molecules useful for applications from diagnosis and assessment of human disease, to environmental monitoring, to detection of pathogens during an emerging infectious disease or a deliberate biological attack.
Maryanne McCormick | EurekAlert!
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