Research done in the last decade has suggested that limiting energy availability, for example, by dietary restriction, may extend the lifespan of different organisms. Now research from scientists at Elixir Pharmaceuticals provides a molecular sensor that supports this theory. A group headed by Javier Apfeld has found that an increased cellular ratio of two small molecules, AMP and ATP correlates well with increased lifespan in nematode worms. ATP is routinely used by the body as a source of energy and generates AMP as a final product. Apfelds group focused on an enzyme, called AMP-1, that is specifically activated by high levels of AMP and results in a cascade of reactions that work to conserve energy stores.
Using an array of genetic and molecular tricks on nematode worms, the team demonstrated that animals with extra copies of the AMP-1 enzyme lived on average 13% longer lives than controls. Other experiments demonstrated that environmental stressors that activate the AMP-1 enzyme, also lead to longer lived animals. In addition, animals that were mutant for this enzyme were less able to cope with the same stressors, thus revealing a protective role for this enzyme in dealing with stress.
The group also examined the influence of AMP-1 on other pathways that regulate lifespan in different animals, specifically the insulin like signaling pathways. Experiments revealed that in some cases, AMP-1 activity contributes to longer lives and may work in parallel with previously established molecular players, such as Daf-16, a transcription factor important during insulin signaling.
Heather Cosel | EurekAlert!
Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
09.12.2016 | Cold Spring Harbor Laboratory
Plant-based substance boosts eyelash growth
09.12.2016 | Fraunhofer-Institut für Angewandte Polymerforschung IAP
Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.
Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
09.12.2016 | Life Sciences
09.12.2016 | Ecology, The Environment and Conservation
09.12.2016 | Health and Medicine