Research done in the last decade has suggested that limiting energy availability, for example, by dietary restriction, may extend the lifespan of different organisms. Now research from scientists at Elixir Pharmaceuticals provides a molecular sensor that supports this theory. A group headed by Javier Apfeld has found that an increased cellular ratio of two small molecules, AMP and ATP correlates well with increased lifespan in nematode worms. ATP is routinely used by the body as a source of energy and generates AMP as a final product. Apfelds group focused on an enzyme, called AMP-1, that is specifically activated by high levels of AMP and results in a cascade of reactions that work to conserve energy stores.
Using an array of genetic and molecular tricks on nematode worms, the team demonstrated that animals with extra copies of the AMP-1 enzyme lived on average 13% longer lives than controls. Other experiments demonstrated that environmental stressors that activate the AMP-1 enzyme, also lead to longer lived animals. In addition, animals that were mutant for this enzyme were less able to cope with the same stressors, thus revealing a protective role for this enzyme in dealing with stress.
The group also examined the influence of AMP-1 on other pathways that regulate lifespan in different animals, specifically the insulin like signaling pathways. Experiments revealed that in some cases, AMP-1 activity contributes to longer lives and may work in parallel with previously established molecular players, such as Daf-16, a transcription factor important during insulin signaling.
Heather Cosel | EurekAlert!
Nanoparticle Exposure Can Awaken Dormant Viruses in the Lungs
16.01.2017 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
Cholera bacteria infect more effectively with a simple twist of shape
13.01.2017 | Princeton University
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).
Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...
Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.
The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...
10.01.2017 | Event News
09.01.2017 | Event News
05.01.2017 | Event News
17.01.2017 | Earth Sciences
17.01.2017 | Materials Sciences
17.01.2017 | Architecture and Construction