A progressive skin disease causing hair loss in adult humans was identified in laboratory mice, providing a genetic tool to study the disease known as alopecia areata (AA).
"Our mouse model has proven to be very useful as a preclinical model to test new treatments for alopecia areata before being used in humans," states lead researcher, John P. Sundberg, D.V.M., Ph.D., of The Jackson Laboratory inBar Harbor, Maine. The study further provided the opportunity to use newly available gene array technology to study AA’s molecular mechanisms.
In this 5-year study, published in the Journal of Investigative Dermatology, researchers identified a virtually identical mouse model for human adult onset AA and were able to reproduce the disease for exploring treatments. Data revealed that the disease has a complicated genetic basis that involves 4 or more genes. These genes include those involved in susceptibility to the disease and genes that regulate pigmentation of the skin and hair. "This [study] provides data for analyzing the genetic candidates responsible for AA as well as insights into other conditions, such as thyroid disorders, which have been associated with AA subsets," as summarized in the November "Clinical Snippets" published in the journal. "Random genome-wide linkage screenings in mice and humans can lead to greater understanding of AA and other complex polygenic diseases."
Sharon Agsalda | EurekAlert!
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Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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