Researchers have uncovered a specific signaling mechanism that contributes to the development of colorectal cancer, one of the most common deadly human cancers. The discovery furthers the understanding of mechanisms that contribute to disease progression and provides new avenues for development of therapies for colorectal cancer.
According to study author, Dr. Marcus F. Neurath from the University of Mainz in Germany, "Several lines of evidence support an important role of TGF-b in the development of colorectal cancer. For instance, mutations of the TGF-b receptor II are frequently observed in patients with colon cancer suggesting a potential role for TGF-b in preventing colon carcinogenesis." However, the molecular mechanisms that control colon cancer are poorly understood. Dr. Neurath and colleagues used a mouse model of colon cancer to show that carcinogenesis in the colon is highly dependent on TGF-b production in tumor infiltrating T lymphocytes. Specifically, a form of the cytokine interleukin (IL)-6 was shown to play a key role and inhibition of TGF-b-dependent IL-6 trans-signaling prevented tumor progression.
The researchers conclude that development and progression of colorectal cancer is dependent on TGF-b production in tumor infiltrating T lymphocytes via a TGF-b –dependent mechanism controlling IL-6 trans-signaling. "Taken together, our data provide novel insights into TGF-b signaling in colorectal cancer and suggest novel therapeutic approaches for colorectal cancer based on inhibition of TGF-b-dependent IL-6 trans-signaling," explains Dr. Neurath.
Heidi Hardman | EurekAlert!
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02.12.2016 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
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The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
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Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...
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