Conventional wisdom holds that cancer cells contain so many mutations that theres no way to return them to the straight and narrow path of their normal neighbors. This has led to cancer treatments that focus on destroying or removing the cancerous cells.
But new research by Dean Felsher, MD, PhD, assistant professor of medicine (oncology) and of pathology at the Stanford University School of Medicine, suggests that cancer cells can be reformed. His work, published in the Oct. 10 advance online issue of Nature, could lead to new ways of treating the most common forms of cancer. Felsher found that turning off just one cancer-causing gene is enough to eliminate aggressive, incurable liver tumors in mice in just four weeks. These cells still had the mutations that made them cancerous in the first place, except that one. He had documented a similar phenomenon in bone cancer two years ago, but liver cancer is more common and difficult to cure. "This is a terrible cancer," said Felsher. "Anything that is encouraging in liver cancer may be important."
Liver cancer is formed in a type of cells called epithelial cells - the same ones that form cancers in the breast, colon and prostate. Felshers findings about liver cancer could also apply to these types of cancer. Felsher hopes his work pushes people to find drugs that specifically hamstring the protein in question: Myc (pronounced "mick"), which is one of the most commonly mutated oncogenes in cancer cells.
Amy Adams | EurekAlert!
Making fuel out of thick air
08.12.2017 | DOE/Argonne National Laboratory
‘Spying’ on the hidden geometry of complex networks through machine intelligence
08.12.2017 | Technische Universität Dresden
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...
An interdisciplinary group of researchers interfaced individual bacteria with a computer to build a hybrid bio-digital circuit - Study published in Nature Communications
Scientists at the Institute of Science and Technology Austria (IST Austria) have managed to control the behavior of individual bacteria by connecting them to a...
Physicists in the Laboratory for Attosecond Physics (run jointly by LMU Munich and the Max Planck Institute for Quantum Optics) have developed an attosecond electron microscope that allows them to visualize the dispersion of light in time and space, and observe the motions of electrons in atoms.
The most basic of all physical interactions in nature is that between light and matter. This interaction takes place in attosecond times (i.e. billionths of a...
Transistors based on carbon nanostructures: what sounds like a futuristic dream could be reality in just a few years' time. An international research team working with Empa has now succeeded in producing nanotransistors from graphene ribbons that are only a few atoms wide, as reported in the current issue of the trade journal "Nature Communications."
Graphene ribbons that are only a few atoms wide, so-called graphene nanoribbons, have special electrical properties that make them promising candidates for the...
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08.12.2017 | Life Sciences
08.12.2017 | Information Technology
08.12.2017 | Information Technology