Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Genetic modification of linseed produces healthier omega 3 and 6 fatty acids


Improved production of polyunsaturated fats in oilseed crops will benefit human health and the environment

In research reported this month in The Plant Cell, scientists succeeded in producing genetically modified linseed plants that accumulate significant levels of very long chain poly-unsaturated fatty acids (PUFA) in seed. This is the first report of the successful engineering of very long chain PUFA into an oilseed crop, and is an excellent example of how genetic engineering of agronomically important species can provide real benefits to human health and nutrition and the environment.

In research reported this month in The Plant Cell, Ernst Heinz at the University of Hamburg (Germany) and colleagues succeeded in producing genetically modified linseed plants that accumulate significant levels of very long chain poly-unsaturated fatty acids (PUFA) in seed. The work is the result of an international collaboration between scientists at several research institutions in Germany (University of Hamburg, BASF Plant Science GmbH and Forschungszentrum Borstel), Rothamsted Research Station in the U.K., and Kansas State University in the U.S. This research is an excellent example of how genetic engineering of agronomically important species can provide real benefits to human health and nutrition and the environment. As demand rises for edible oils that are low in saturated fats and high in poly-unsaturated fats, in particular very long chain omega 3- and omega 6-poly-unsaturated fats, the production of these oils in plants may reduce environmentally and economically unsustainable pressures on both wild and farmed fisheries.

Fatty acids are long straight chains of carbon atoms, ranging in length from about 12 to 22 carbons (C12 to C22). They have one water-soluble end and one oil-soluble methyl end, and are studded with hydrogen atoms along the length of the carbon chain. They are essential components of the membranes of all living organisms. Fatty acid chains that are linked by single bonds between carbon atoms are said to be "saturated" by hydrogen atoms, whereas the introduction of double bonds between carbon atoms leads to correspondingly fewer bonds to hydrogen atoms along the chain, and such fatty acids are said to be "unsaturated". A "mono-unsaturated" fatty acid contains a single double bond within the carbon chain, whereas "poly-unsaturated" fatty acids contain two or more double bonds.

PUFA are increasingly recognized as important components of a healthy human diet. Increased consumption, in particular of the very long chain PUFA such as those found in fish oils, has been linked to a decreased risk of heart disease, and also to a variety of other health benefits, including protection against inflammatory diseases such as arthritis, irritable bowel syndrome and some cancers, and the promotion of healthy brain and eye development in infants. Scientists have been working on engineering the production of the very long chain PUFA in plants, because increased consumption of fish and fish oils is associated with other nutritional and environmental problems. First, it is recommended that consumption of many types of fish be limited due to widespread contamination with pollutants, such as heavy metals and dioxins. Second, world wide fish stocks are being rapidly depleted, and fish farming is associated with its own set of environmental issues. Therefore, engineering the production of very long chain PUFAs into oilseed crops could confer significant advantages in terms of both human nutrition and the environment.

Oilseed crops, such as canola, safflower, and linseed, typically accumulate a high proportion of C18 PUFA such as linoleic acid and alpha-linoleic acid in their seed. These are called "essential" fatty acids for humans, because they are not synthesized in the human body and must be obtained from dietary sources. Once consumed, they may be metabolized into very long chain (C20 and C22) PUFA in the human body. However, this process is slow and inefficient compared to the direct consumption of C20 and C22 PUFA that may be obtained from fish oils. Oilseed crop species contain all of the proteins and enzymes necessary for the biosynthesis of the range of fatty acids present in seed oil, but they lack the few additional enzymes (certain fatty acyl desaturases and elongases) necessary for the biosynthesis of very long chain PUFA.

Dr. Heinz and his colleagues produced linseed (Linum usitatissimum) and tobacco (Nicotiana tabacum) plants that synthesize very long chain PUFA in their seed by introducing genes for fatty acyl desaturases and elongases in genetic transformation experiments. First, protein sequences for fatty acyl desaturases and elongases were analyzed from a variety of organisms that produce very long-chain PUFA, including a fungus (Mortierella alpina), alga (Phaeodactylum tricornutum), moss (Physcomitrella patens), nematode (Caenorhabditis elegans), and another plant (Borago officinalis). DNA coding sequences for these genes were then introduced into linseed and tobacco plants, and expression of the proteins directed into the seed with the use of seed-specific gene promoter sequences. The best results were obtained with the use of the plant and algal gene sequences. These transgenic plants accumulated significant levels of very long chain PUFA in their seed. Analysis of fatty acid profiles of these plants also allowed the researchers to identify constraints on the accumulation of the most desirable PUFA, pointing the way to future experiments aimed at making improvements in the levels of accumulation and specific profiles of very long chain PUFAs in genetically modified oilseed crops. In addition to the possibility of providing healthier, more nutritious oils for human consumption, this work will lead to the production of high quality animal feed that could improve the PUFA content of animal products such as meat, eggs, and dairy foods.

Nancy Eckardt | EurekAlert!
Further information:

More articles from Life Sciences:

nachricht Gene therapy shows promise for treating Niemann-Pick disease type C1
27.10.2016 | NIH/National Human Genome Research Institute

nachricht 'Neighbor maps' reveal the genome's 3-D shape
27.10.2016 | International School of Advanced Studies (SISSA)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Etching Microstructures with Lasers

Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.

This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...

Im Focus: Light-driven atomic rotations excite magnetic waves

Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion

Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

How nanoscience will improve our health and lives in the coming years

27.10.2016 | Materials Sciences

OU-led team discovers rare, newborn tri-star system using ALMA

27.10.2016 | Physics and Astronomy

'Neighbor maps' reveal the genome's 3-D shape

27.10.2016 | Life Sciences

More VideoLinks >>>