Heart disease is Europes leading cause of death, but new research shows that the diseases toll would be much greater had natural selection not shifted the frequency of susceptibility genes over the past few tens of thousands of years. The work underscores the role of ancient natural selection in shaping contemporary public health.
The findings are reported by Matthew Rockman, Dagan Loisel, and Greg Wray at Duke University, Matthew Hahn at UC Davis, and David Goldstein and Nicole Soranzo at University College London. By analyzing DNA sequences from humans and other primates and comparing sequences among and within human populations, the researchers have cast light on the evolutionary history of a single DNA base pair that has been shown to influence heart disease.
The genetic trait under study concerns a particular base pair of DNA – one of billions in the human genome – that helps regulate the gene stromelysin-1, or MMP-3. The identity of the DNA base at this position differs between individuals and influences the rate of production of the genes product, an enzyme that degrades the extracellular matrix that makes up the walls of arteries.
Heidi Hardman | EurekAlert!
Study identifies RNA molecule that shields breast cancer stem cells from immune system
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An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.
In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...
Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...
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22.05.2017 | Event News
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23.05.2017 | Physics and Astronomy