Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

K-State researcher working to improve alternatives to equine antibiotics

23.07.2004


Antibiotics can save lives. But the increasing occurrence of antibiotic-resistant bacteria presents a number of challenges for researchers in medicine.



Veterinary medicine is no exception and Dr. Elizabeth Davis, assistant professor of equine internal medicine at Kansas State University, is working to help improve alternative methods for combating infectious diseases in horses. "In veterinary medicine and medicine in general, we’re running out of antibiotics, so we have to be extremely careful of the antibiotics we use, the duration that we use them and the species that we use them in," Davis said.

To help better prepare the horse industry for a limited number of effective antibiotics, Davis has researched the presence of antimicrobial peptides in horses. According to Davis, antimicrobial peptides are produced by the body as an immediate immunological response to pathogens and generally target and kill bacteria. Davis recently found genetic information relating to two of these peptides in horses.


The idea of stimulating the immune system to help animals efficiently and naturally fight infection is nothing new, Davis said. There are a number of commercial immune stimulants on the market, but they are rather mild and often have to be used in conjunction with antibiotics.

Specific DNA sequences found within one such stimulant are known as CpG motifs. These specific DNA sequences might be what stimulate an effective immunological response, Davis said. With hopes of helping to develop more powerful immune stimulants, Davis is examining different DNA sequences containing immunostimulatory CpG motifs to identify which sequences contain the most effective motifs.

"In effect, what we may be able to do is specifically turn on antimicrobial peptide production and other immune response factors that help ward off infection," Davis said. "What it would mean is we hope we could use shorter antibiotic therapy."

Davis said she also hopes to find which motifs are the most stimulating to equine immune cells as well as how the immune response is initiated. Such research would continue to drive the development of more effective commercial immune stimulants.

"I think we could improve on something that works well," Davis said about the commercial stimulants. "The ultimate goal would be to reduce antibiotic usage for infectious diseases. People do commonly use the commercial products, so I think there would be some interest to have something that was better."

Davis is completing her Ph.D. under the direction of Dr. Frank Blecha.

"The antimicrobial peptide cloning/sequencing work has been part of my graduate work; the immunomodulation with CpG DNA studies are my current focus," Davis said.

Elizabeth Davis | EurekAlert!
Further information:
http://www.vet.k-state.edu

More articles from Life Sciences:

nachricht Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
09.12.2016 | Cold Spring Harbor Laboratory

nachricht Plant-based substance boosts eyelash growth
09.12.2016 | Fraunhofer-Institut für Angewandte Polymerforschung IAP

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>