Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Sponge substance works well with yew derivative to thwart cancer cell proliferation

15.07.2004


A drug derived from an ocean-growing sponge teams up to enhance the performance of the yew tree derivative Taxol® (paclitaxel) in preventing the growth of cancer cells, according to research published in the July 15 issue of the journal Cancer Research. Indeed, discodermolide, a novel drug isolated from the marine sponge Discodermia dissoluta, works with paclitaxel to thwart tumor cell growth--with several times the efficacy that either drug alone exerts on proliferating cancer cells.

Studies by Mary Ann Jordan, Ph.D., a scientist at the University of California, Santa Barbara, and an international team of cancer researchers including postdoctoral fellows Stephane Honore, Ph.D., and Kathryn Kamath, Ph.D., demonstrate that the combination of the two drugs inhibited proliferation of human lung cancer cells by 41 percent. Administered alone, either discodermolide or paclitaxel prevented the cancer cell growth by only 9.6 or 16 percent, respectively. The drugs also combined to induce programmed cell death, or apoptosis, in the lung cancer cells.

"Our results indicate that Taxol® and discodermolide have the potential to improve cancer patients’ responses and reduce undesirable side effects when the two drugs are administered together," Jordan said.



The drugs, which stem from naturally occurring sources, work in concert to stabilize the assembly/disassembly process of microtubules in cells. Microtubules--lengthy polymers made up of protein bundles, called tubulin--form long, straw-like cylinders that help shape the skeletal structure within cells and also move cellular components within the cell, including vesicles, granules, organelles like mitochondria, and chromosomes. Their attachment with chromosomes, the DNA genetic material in cells, is critical for cell replication and growth. Microtubules normally exist in a state of dynamic instability, where the polymers grow rapidly--longer or shorter, depending on the need of the cells.

In this study, discodermolide and paclitaxel combined to alter the overall microtubule dynamics by 71 percent when administered together. Alone, they each reduced microtubule dynamic instability by 24 percent.

By altering the stability dynamics of microtubules, paclitaxel and discodermolide limit cancer cells ability to duplicate DNA and divide. The cells are stuck in a pre-division stage of the cell cycle called G2/M. Cancer cells that are restricted to the pre-division stage of the cell cycle cannot divide and ultimately die, thus reducing proliferation of tumor cells.

Both drugs work by binding to the microtubules. Because of their lengthy structure and the number of drug binding sites normally associated with them, microtubules are unique receptors for drugs within cells.

Paclitaxel is currently an approved therapeutic for control of cancer growth. Discodermolide is currently under study in phase one clinical studies.

Jordan is an adjunct professor and research biologist in the Molecular, Cellular, and Developmental Biology department, University of California, Santa Barbara. In the paclitaxel/discodermolide studies, she collaborated with researchers from the Universite de la Mediterranee, Marseille, France; Albert Einstein College of Medicine, Bronx, N.Y.; and the University of California, Santa Barbara, Calif. The work was supported by grants from the National Institutes of Health.

Russell Vanderboom | EurekAlert!
Further information:
http://www.aacr.org

More articles from Life Sciences:

nachricht CRISPR meets single-cell sequencing in new screening method
19.01.2017 | CeMM Forschungszentrum für Molekulare Medizin der Österreichischen Akademie der Wissenschaften

nachricht Toward a 'smart' patch that automatically delivers insulin when needed
18.01.2017 | American Chemical Society

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Global threat to primates concerns us all

19.01.2017 | Ecology, The Environment and Conservation

Scientist from Kiel University coordinates Million Euros Project in Inflammation Research

19.01.2017 | Awards Funding

The Great Unknown: Risk-Taking Behavior in Adolescents

19.01.2017 | Studies and Analyses

VideoLinks
B2B-VideoLinks
More VideoLinks >>>