Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Deleting neural STAT3 protein in mice

02.04.2004


Protein molecules that help maintain a healthy body temperature, electrolyte balance, respiration, heart rate, and other critical functions, also appear to regulate weight and fertility, according to Yale researchers.



STAT3 proteins are regulatory molecules that signal cell functions for activating genes. When the STAT3 molecules are disrupted in mice, the animals either die before they are born, or overeat and become obese, diabetic and infertile, according to the study published in the Proceedings of the National Academy of Sciences.

Mice with disrupted STAT3 begin to gain weight at six to eight weeks old and weigh twice as much as normal mice by adulthood. The excess body mass was almost exclusively fat. Livers of the mice also were severely enlarged with fat deposits.


The senior author, Xin-Yuan Fu, of the Department of Pathology at Yale School of Medicine, said the study contradicts previous research that concluded STAT3 plays no role in reproduction and growth and only a marginal role in glucose regulation.

The study also raises more questions about leptin, a protein produced by fat cells and thought to play an important role in signaling the reduction of body fat.

"The mutant mice had an oversupply of leptin, yet still became obese, suggesting a leptin-resistant condition," Fu said.

During embryonic development, STAT3 is found in areas of the brain where nerve cell proliferation and differentiation take place. In adults, STAT3 has been implicated in the regulation of energy balance through its effect on leptin. This new study provides direct evidence for this role.

Fu said the study shows that body weight and fertility are essentially controlled through STAT3 functions in the brain. These discoveries, he said, could help in the development of new therapeutics to treat obesity and infertility.


Citation: Proceedings of the National Academy of Sciences, Vol. 101: 4661-4666 (March 30, 2004)

Jacqueline Weaver | EurekAlert!
Further information:
http://www.yale.edu/

More articles from Life Sciences:

nachricht New application for acoustics helps estimate marine life populations
16.01.2018 | University of California - San Diego

nachricht Unexpected environmental source of methane discovered
16.01.2018 | University of Washington Health Sciences/UW Medicine

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

Im Focus: A thermometer for the oceans

Measurement of noble gases in Antarctic ice cores

The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

White graphene makes ceramics multifunctional

16.01.2018 | Materials Sciences

Breaking bad metals with neutrons

16.01.2018 | Materials Sciences

ISFH-CalTeC is “designated test centre” for the confirmation of solar cell world records

16.01.2018 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>