Scientists at Emory University School of Medicine were able to enhance significantly the re-growth of damaged peripheral nerves in mice by treating them with enzymes that counteracted a growth-blocking mechanism. The research offers the potential for improving functional recovery after peripheral nerve injuries. The Emory scientists were led by Arthur English, PhD, professor of cell biology, with faculty colleagues Robert McKeon, PhD and Erica Werner, PhD and former Emory student M.L. Groves. Results of the research will be presented at the annual meeting of the Society for Neuroscience on November 8 in New Orleans.
Peripheral nerves extend from the spinal cord to targets in the periphery such as muscle and skin. Individual peripheral nerves contain thousands of individual fibers, called axons, which project to specific targets. When a peripheral nerve is damaged, axons between the injury site and muscle or skin degenerate and function is lost. Although peripheral nerve axons are capable of regenerating after such injuries, in humans this regeneration is modest at best and there currently is no effective clinical treatment.
One reason peripheral nerves do not regenerate well is the presence of growth inhibitory substances, called proteoglycans, within the environment of the damaged nerve. In an effort to improve the ability of axons to regenerate, the Emory scientists attempted to modify this inhibitory environment following peripheral nerve injury in mice. They treated the peripheral portion of severed nerves with each of three enzymes that degrade specific types of proteoglycans.
Holly Korschun | EurekAlert!
Signaling Pathways to the Nucleus
19.03.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau
In monogamous species, a compatible partner is more important than an ornamented one
19.03.2018 | Max-Planck-Institut für Ornithologie
Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...
On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...
The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...
At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.
When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...
At the ILA Berlin, hall 4, booth 202, Fraunhofer FHR will present two radar sensors for navigation support of drones. The sensors are valuable components in the implementation of autonomous flying drones: they function as obstacle detectors to prevent collisions. Radar sensors also operate reliably in restricted visibility, e.g. in foggy or dusty conditions. Due to their ability to measure distances with high precision, the radar sensors can also be used as altimeters when other sources of information such as barometers or GPS are not available or cannot operate optimally.
Drones play an increasingly important role in the area of logistics and services. Well-known logistic companies place great hope in these compact, aerial...
16.03.2018 | Event News
13.03.2018 | Event News
08.03.2018 | Event News
19.03.2018 | Trade Fair News
19.03.2018 | Life Sciences
19.03.2018 | Life Sciences