Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Emory scientists use enzymes to enhance regeneration of damaged peripheral nerves in mice

10.11.2003


Scientists at Emory University School of Medicine were able to enhance significantly the re-growth of damaged peripheral nerves in mice by treating them with enzymes that counteracted a growth-blocking mechanism. The research offers the potential for improving functional recovery after peripheral nerve injuries. The Emory scientists were led by Arthur English, PhD, professor of cell biology, with faculty colleagues Robert McKeon, PhD and Erica Werner, PhD and former Emory student M.L. Groves. Results of the research will be presented at the annual meeting of the Society for Neuroscience on November 8 in New Orleans.



Peripheral nerves extend from the spinal cord to targets in the periphery such as muscle and skin. Individual peripheral nerves contain thousands of individual fibers, called axons, which project to specific targets. When a peripheral nerve is damaged, axons between the injury site and muscle or skin degenerate and function is lost. Although peripheral nerve axons are capable of regenerating after such injuries, in humans this regeneration is modest at best and there currently is no effective clinical treatment.

One reason peripheral nerves do not regenerate well is the presence of growth inhibitory substances, called proteoglycans, within the environment of the damaged nerve. In an effort to improve the ability of axons to regenerate, the Emory scientists attempted to modify this inhibitory environment following peripheral nerve injury in mice. They treated the peripheral portion of severed nerves with each of three enzymes that degrade specific types of proteoglycans.


During the first two weeks after the injury, axons regenerated through enzyme-treated tissues much more effectively than through untreated tissues. Not only did the axons regenerate, those that did extended more than twice as far.

"This study shows that treatment with enzymes that degrade proteoglycans offers the potential to enhance regeneration, and may lead to improved recovery of function after peripheral nerve injuries," says Dr. English.

Holly Korschun | EurekAlert!
Further information:
http://www.emory.edu/

More articles from Life Sciences:

nachricht Could this protein protect people against coronary artery disease?
17.11.2017 | University of North Carolina Health Care

nachricht Microbial resident enables beetles to feed on a leafy diet
17.11.2017 | Max-Planck-Institut für chemische Ökologie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

NASA detects solar flare pulses at Sun and Earth

17.11.2017 | Physics and Astronomy

NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures

17.11.2017 | Health and Medicine

The importance of biodiversity in forests could increase due to climate change

17.11.2017 | Studies and Analyses

VideoLinks
B2B-VideoLinks
More VideoLinks >>>