Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Standard improves tests of male DNA

13.10.2003


Mother Goose tells us that boys are made of "snips and snails and puppy dog tails." She was clearly misinformed about the snails and tails, but she was on to something with the snips. What you really need to build a boy is a "Y" chromosome, and it turns out that SNPs (single nucleotide polymorphisms), known by the biotech cognoscente as simply "snips," can be helpful in sorting out who fathered the boy. If DNA can be thought of as an instruction book for building a specific person, then SNPs are single letters at an exact location in that book that tend to vary among individuals.


Columns of a DNA gel show the sizes of Y chromosome fragments from 6 male and 1 female sample (empty lane third from right).



A new Standard Reference Material (SRM) issued by the National Institute of Standards and Technology (NIST) uses both SNPs and STRs (sections where three to five DNA "letters" form repeating patterns) to help improve the reliability of laboratory analyses of male DNA. The result of several years of research, the standard consists of six vials of very carefully analyzed DNA. Five are male samples, and one is female. Laboratories that perform forensics or paternity DNA analyses can use the SRM to double check the accuracy of their equipment and test procedures for analyzing the Y chromosome. It also may be helpful for population studies that study whether the human race evolved from one or many "Adams."

Each vial comes with certified DNA sequences for 22 different STR locations and 42 different SNPs. NIST research chemist Margaret Kline provided a detailed description of the SRM and the methods used in preparing it at the 14th International Symposium on Human Identification in Phoenix, Ariz., on Oct. 1, 2003.


Gail Porter | EurekAlert!
Further information:
http://www.nist.gov/

More articles from Life Sciences:

nachricht Topologische Quantenchemie
21.07.2017 | Max-Planck-Institut für Chemische Physik fester Stoffe

nachricht Topological Quantum Chemistry
21.07.2017 | Max-Planck-Institut für Chemische Physik fester Stoffe

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

Im Focus: On the way to a biological alternative

A bacterial enzyme enables reactions that open up alternatives to key industrial chemical processes

The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....

Im Focus: The 1 trillion tonne iceberg

Larsen C Ice Shelf rift finally breaks through

A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...

Im Focus: Laser-cooled ions contribute to better understanding of friction

Physics supports biology: Researchers from PTB have developed a model system to investigate friction phenomena with atomic precision

Friction: what you want from car brakes, otherwise rather a nuisance. In any case, it is useful to know as precisely as possible how friction phenomena arise –...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

The technology with a feel for feelings

12.07.2017 | Event News

 
Latest News

NASA looks to solar eclipse to help understand Earth's energy system

21.07.2017 | Earth Sciences

Stanford researchers develop a new type of soft, growing robot

21.07.2017 | Power and Electrical Engineering

Vortex photons from electrons in circular motion

21.07.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>