Discovery highlights molecular screening work at Institute of Chemistry and Cell Biology
Boston, Mass. — Scientists studying how cells know when and where to divide now have a new tool to study the final fast stage of cell division. The first experiments using this new tool reveal some of the molecular conversation that helps a cell tightly choreograph the time and place of pinching into two cells. In the March 14 Science, researchers from Harvard Medical School (HMS) and colleagues report the discovery of a small compound called "blebbistatin" that blocks the final cleavage motion after cells have duplicated and separated their chromosomes.
Blebbistatin works by interfering only with a type of myosin necessary for the final stage of cell division, said HMS postdoctoral fellow Aaron Straight, first author of the paper. The final stages of cell division happens in mere minutes – too fast for scientific scrutiny. Other inhibitors that slow or stop cell contraction also damage other parts of the cell, obscuring molecular details. Blebbistatin appears to works with the precision of a scalpel, both freezing the action and preserving other molecules and functions for detailed study.
Myosin – the protein responsible for the contraction of muscle - is central to many aspects of human biology, including heartbeat, breathing and movement. Myosin mutations can cause heart disease, deafness, blood disorders and blindness. Myosin is also necessary for single cells to divide. Myosin is required for each and every cell division in the human body, beginning with one fertilized cell to the billions of cells in an adult, Straight said. Myosin also powers the movement of cells through the body, including immune cells that are trying to kill an invading pathogen and nerve cells seeking to make the proper connections in the developing brain.
John Lacey | EurekAlert!
North and South Cooperation to Combat Tuberculosis
22.03.2018 | Universität Zürich
Researchers Discover New Anti-Cancer Protein
22.03.2018 | Universität Basel
An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.
The incidence of liver cancer, also known as hepatocellular carcinoma, is steadily increasing. In the last twenty years, the number of cases has almost doubled...
In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.
Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...
Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.
They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...
A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...
For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.
In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...
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