Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Enzyme controls ’good cholesterol’

27.02.2003


A recently discovered enzyme called endothelial lipase regulates the structure, metabolism and blood concentration of high density lipoprotein (HDL), the so-called "good cholesterol," said researchers from Baylor College of Medicine in a report in the online version of the Proceedings of the National Academy of Sciences.



In a series of studies in mice, Dr. Lawrence Chan, chief of the section of endocrinology and metabolism at Baylor, his co-workers and colleagues from the section of cardiology and atherosclerosis have found that when mice lack this enzyme, the particles of HDL in their blood are much larger than normal.

"We don’t know if it is good or bad that the HDL becomes larger," said Chan. "We were always taught that high levels of HDL are good for you because HDL carries cholesterol from the outer areas of the body back to the liver where it is excreted as bile."


High levels of HDL may also inhibit inflammation, a newly accepted factor in coronary heart disease, Chan said.

"It also protects the vascular wall," he said. "It may also slow down the oxidation of low density lipoprotein (the so-called bad cholesterol). Oxidized LDL is very bad."

A variant of the enzyme that is found in approximately 26 percent of people is associated with high levels of HDL, he said. He and his colleagues are studying the fate of patients with this type of enzyme to determine whether it is beneficial or not.

Once they determine whether the variant form of HDL is good or bad, it can become a target for drug developers who will attempt to manipulate levels of "good" cholesterol through this mechanism.

One concern is that the larger particles of HDL might slow the transport of cholesterol back to the liver, which probably would not be good, said Chan. While HDL might have all the good actions including working against inflammation and protecting the vascular wall, that would have to be balanced against the interruption of cholesterol transport to the liver.

In his experiments, he found that metabolism of HDL is a lot slower without the enzyme.

"That’s why the concentration goes up as the HDL accumulates," he said.

Others who participated in the study included Drs. Ke Ma, Mehmet Cilingiroglu, Christie M. Ballantyne and Ali J. Marian, all of Baylor, and Dr. James Otvos of LipoScience of Raleigh, NC.

Anissa Anderson Orr | EurekAlert!
Further information:
http://research.bcm.tmc.edu/

More articles from Life Sciences:

nachricht Researchers uncover protein-based “cancer signature”
05.12.2016 | Universität Basel

nachricht The Nagoya Protocol Creates Disadvantages for Many Countries when Applied to Microorganisms
05.12.2016 | Leibniz-Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

IHP presents the fastest silicon-based transistor in the world

05.12.2016 | Power and Electrical Engineering

InLight study: insights into chemical processes using light

05.12.2016 | Materials Sciences

High-precision magnetic field sensing

05.12.2016 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>